quinapril, Accupril

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Tablets: 5, 10, 20 and 40 mg

STORAGE: Tablets and solutions should be stored at room temperature 15 C to 30 C (59 F to 86 F).

DOSING: The recommended dose for treating high blood pressure is 10-80 mg a day as a single dose or in two doses every 12 hours. Start at 5 to 20 mg daily. The initial dose for heart failure is 5 mg every 12 hours and the maintenance dose is 20 to 40 mg a day as a single dose or in two divided doses every 12 hours. Quinapril should be taken on an empty stomach because food reduces its absorption.

DRUG INTERACTIONS: The use of ACE inhibitors with potassium supplements, salt substitutes or diuretics (for example, spironolactone [Aldactone]) that increase potassium in the blood may lead to excessive potassium levels in the body. Potassium levels should be closely monitored whenever ace inhibitors are use in combination with these drugs.

Patients receiving diuretics or are dehydrated or have low blood sodium may experience excessive reduction in blood pressure when quinapril is started. Stopping the diuretic or increasing salt intake prior to taking quinapril may prevent this excessive reduction in blood pressure. 

There have been reports that aspirin and other nonsteroidal antiinflammatory drugs (NSAIDs) such as ibuprofen (Advil, Children's Advil/Motrin, Medipren, Motrin, Nuprin, PediaCare Fever, etc.), indomethacin (Indocin, Indocin-SR), and naproxen (Anaprox, Naprelan, Naprosyn, Aleve) may reduce the effects of ACE inhibitors.

Quick GuideHow to Lower Blood Pressure: Exercise Tips (Pictures)

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