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- What is quinapril, and how does it work (mechanism of action)?
- What brand names are available for quinapril?
- Is quinapril available as a generic drug?
- Do I need a prescription for quinapril?
- What are the side effects of quinapril?
- What is the dosage for quinapril?
- Which drugs or supplements interact with quinapril?
- Is quinapril safe to take if I'm pregnant or breastfeeding?
- What else should I know about quinapril?
What is quinapril, and how does it work (mechanism of action)?
Quinapril belongs in a class of drugs called angiotensin converting enzyme (ACE) inhibitors. ACE inhibitors are used for treating high blood pressure and heart failure and for preventing kidney failure due to high blood pressure and diabetes. Other drugs in this class are enalapril (Vasotec), ramipril (Altace), captopril (Capoten), fosinopril (Monopril), benazepril (Lotensin), lisinopril (Zestril, Prinivil), moexipril (Univasc) and trandolapril (Mavik). ACE is important because it produces angiotensin II. Angiotensin II contracts the muscles of the arteries in the heart and the rest of the body, narrowing the arteries and thereby elevating blood pressure. In the kidney, the narrowing caused by angiotensin II decreases blood flow and increases the arterial filtration pressure in the kidney. ACE inhibitors such as quinapril lower blood pressure by inhibiting the formation of angiotensin II, thereby relaxing the arterial muscles and enlarging the arteries. This increases the flow of blood and oxygen to the heart so that it can pump blood more efficiently. The enlargement of the arteries elsewhere in the body also makes it easier for the heart to pump blood. This is particularly beneficial when there is heart failure. In the kidneys ACE inhibitors increase blood flow and reduce the filtration pressure in the kidneys. Quinapril was approved by the FDA in November 1991.
What brand names are available for quinapril?
Is quinapril available as a generic drug?
GENERIC AVAILABLE: Yes
Do I need a prescription for quinapril?
What are the side effects of quinapril?
Quinapril is generally well tolerated, and side effects are usually mild and transient. A dry, persistent cough has been reported with the use of quinapril and other ACE inhibitors. Coughing resolves after discontinuing the medication.
Other side effects include:
- abdominal pain,
- loss of taste,
- loss of appetite,
- nausea, vomiting,
- fainting, and
- numbness or tingling in the hands or feet.
Quinapril and other ACE inhibitors may also cause kidney failure and increased levels of potassium in the blood. The most serious but very rare side effects are liver failure and angioedema (swelling of lips and throat).
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