quetiapine, Seroquel, Seroquel XR (cont.)

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In animals, quetiapine has been associated with the development of cataracts, and cataracts have been reported in patients using quetiapine for prolonged periods. Although it is not clear if quetiapine was responsible for the cataracts seen in humans, eye examinations by slit-lamp (to identify cataracts before they impair vision) are recommended at the beginning of treatment and every six months during treatment. If cataracts form, treatment should be discontinued. Quetiapine may increase blood concentrations of cholesterol and triglycerides by 11% and 17%, respectively.

There is an increased risk of hyperglycemia (high blood glucose) and diabetes-related events in patients taking atypical antipsychotics, including quetiapine. Patients should be tested during treatment for elevated blood-sugars. Additionally, persons with risk factors for diabetes, including obesity or a family history of diabetes, should have their fasting levels of blood sugar tested before starting treatment and periodically throughout treatment to detect the onset of diabetes. Any patient developing symptoms that suggest diabetes during treatment should be tested for diabetes.

Elderly patients with dementia-related psychosis treated with antipsychotics are at an increased risk of death. There is an increased risk of suicidal thinking and behavior in children, adolescents and young adults taking antidepressants for major depression and other psychiatric disorders.

Medically Reviewed by a Doctor on 12/12/2014

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