quetiapine, Seroquel, Seroquel XR (cont.)

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Medical and Pharmacy Editor:

SIDE EFFECTS: The most common side effects for quetiapine are:

Other important side effects include a potentially fatal complex referred to as neuroleptic malignant syndrome (NMS), in which patients may have:

WARNING: Quetiapine can cause orthostatic hypotension (a drop in blood pressure upon standing that can lead to dizziness or fainting) especially during the first 3-5 day period of treatment, when it is restarted after temporary discontinuation, and after an increase in the dose. The risk of orthostatic hypotension is about 1 in 100 (one of every hundred patients who take quetiapine). Quetiapine frequently causes tiredness (1 in 5 patients), especially during the first 3-5 days of treatment. Because of this tiredness, care should be exercised in any activity requiring mental alertness such as operating a motor vehicle or hazardous machinery. Less common side effects include seizures (1 in 125 patients) and hypothyroidism (1 in 250 patients).

As with other antipsychotics, long-term use of quetiapine may lead to irreversible tardive dyskinesia, a neurologic disease which consists of involuntary movements of the jaw, lips, and tongue.

Medically Reviewed by a Doctor on 12/12/2014

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