quetiapine, Seroquel, Seroquel XR

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GENERIC NAME: quetiapine

BRAND NAME: Seroquel, Seroquel XR

DRUG CLASS AND MECHANISM: Quetiapine is an oral atypical antipsychotic drug used for treating schizophrenia and bipolar disorder. Although the mechanism of action of quetiapine is unknown, like other atypical anti-psychotics, it inhibits communication among nerves of the brain. It does this by blocking receptors on the nerves for several neurotransmitters, the chemicals that nerves use to communicate with each other. It is thought that its beneficial effect is due to blocking of the dopamine type 2 (D2) and serotonin type 2 (5-HT2) receptors. The FDA approved quetiapine in September 1997.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Tablets: 25, 50, 100, 200, 300 and 400 mg. Tablet (Extended Release): 50, 150, 200, 300 and 400 mg

STORAGE: Tablets should be stored at room temperature, 15 C to 30 C (59 F to 86 F).

PRESCRIBED FOR: Quetiapine is used alone or in combination with other drugs to treat schizophrenia and bipolar disorder. It also is used for treating major depression in combination with antidepressants.

DOSING: Immediate release quetiapine usually is taken two or three times daily. Extended release quetiapine is taken once daily. The dose usually is increased slowly over several days or weeks to achieve the desired effect. Quetiapine can be taken with or without food.

The initial dose for bipolar disorder is 50 mg twice daily (100 mg/day) of immediate release quetiapine. The dose can be increased by 100 mg/day to a daily dose of 400 mg/day. Most patients respond to 400-800 mg/day. Doses greater than 800 mg/d have not been studied. The starting dose is 300 mg once daily and the target dose is 400-800 mg once daily when using extended release tablets.

Medically Reviewed by a Doctor on 4/1/2013



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