quetiapine, Seroquel, Seroquel XR

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GENERIC NAME: quetiapine

BRAND NAME: Seroquel, Seroquel XR

DRUG CLASS AND MECHANISM: Quetiapine is an oral atypical antipsychotic drug used for treating schizophrenia and bipolar disorder. Although the mechanism of action of quetiapine is unknown, like other atypical anti-psychotics, it inhibits communication among nerves of the brain. It does this by blocking receptors on the nerves for several neurotransmitters, the chemicals that nerves use to communicate with each other. It is thought that its beneficial effect is due to blocking of the dopamine type 2 (D2) and serotonin type 2 (5-HT2) receptors. The FDA approved quetiapine in September 1997.

PRESCRIBED FOR: Quetiapine is used alone or in combination with other drugs to treat schizophrenia and bipolar disorder. It also is used for treating major depression in combination with antidepressants.

SIDE EFFECTS: The most common side effects for quetiapine are:

Other important side effects include a potentially fatal complex referred to as neuroleptic malignant syndrome (NMS), in which patients may have:

  • high fevers,
  • muscle rigidity,
  • altered mental status,
  • irregular pulse or blood pressure,
  • rapid heart rate,
  • excessive sweating, and
  • heart arrhythmias.
Medically Reviewed by a Doctor on 12/12/2014



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