quetiapine, Seroquel, Seroquel XR
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
GENERIC NAME: quetiapine
BRAND NAME: Seroquel, Seroquel XR
DRUG CLASS AND MECHANISM: Quetiapine is an oral atypical antipsychotic drug used for treating schizophrenia and bipolar disorder. Although the mechanism of action of quetiapine is unknown, like other atypical anti-psychotics, it inhibits communication among nerves of the brain. It does this by blocking receptors on the nerves for several neurotransmitters, the chemicals that nerves use to communicate with each other. It is thought that its beneficial effect is due to blocking of the dopamine type 2 (D2) and serotonin type 2 (5-HT2) receptors. The FDA approved quetiapine in September 1997.
PRESCRIBED FOR: Quetiapine is used alone or in combination with other drugs to treat schizophrenia and bipolar disorder. It also is used for treating major depression in combination with antidepressants.
SIDE EFFECTS: The most common side effects for quetiapine are:
Other important side effects include a potentially fatal complex referred to as neuroleptic malignant syndrome (NMS), in which patients may have:
Medically Reviewed by a Doctor on 12/12/2014
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