Between 15 and 20 weeks of pregnancy, your health care provider may offer you a quad marker screen. The test can only be performed during the 15th and 20th week of pregnancy.
What Substances Are Measured During a Quad Marker Screen?
The blood sample is sent to a laboratory and tested for the presence of the following four substances, which are normally found in the baby's blood, brain, spinal fluid, and amniotic fluid:
Alpha-fetoprotein (AFP): A protein produced by the baby's liver.
Unconjugated Estriol (UE): A protein produced in the placenta and in the baby's liver.
Human Chorionic Gonadotropin (hCG): A hormone produced by the placenta.
Inhibin-A: A hormone produced by the placenta.
The expected amount of these substances normally found in the mother's bloodstream changes each week of pregnancy, so it is important to tell your health care providers how far along you are in your pregnancy. High AFP levels may indicate that the baby has an open neural tube defect. High AFP levels may also indicate that the fetus is older than was thought or that the woman is expecting twins. Lower than normal AFP levels could indicate that a woman is at higher risk for having a baby with Down syndrome.
Levels of hCG and Inhibin-A are higher than normal when a woman has an increased risk of having a baby with Down syndrome. Lower than normal levels of Estriol may also indicate that a woman is at high risk for having a baby with Down syndrome.
Is the Quad Marker Screen Safe?
Yes. The quad marker screen is a safe and useful screening test for families concerned about birth defects or genetic diseases. It is a test that carries no risk to the baby, since a blood sample is taken only from the mother.
There are many symptoms involved in the 1st, 2nd and 3rd trimesters of pregnancy. The first early pregnancy symptom is typically a missed period, but others include breast swelling and tenderness, nausea and sometimes vomiting, fatigue and bloating. Second trimester symptoms include backache, weight gain, itching, and possible stretch marks. Third trimester symptoms are additional weight gain, heartburn, hemorrhoids, swelling of the ankles, fingers, and face, breast tenderness, and trouble sleeping. Read more to learn about recommended procedures and tests for each stage of a healthy pregnancy.
Preeclampsia is related to increased blood pressure and protein in the mother's urine. Preeclampsia typically begins after the 20th week of pregnancy. When preeclampsia causes seizures, it is termed "eclampsia" and is the second leading cause of maternal death of in the US. Preeclampsia is the leading cause of fetal complications. Risk factors for preeclampsia include high blood pressure, obesity, multiple births, and women with preexisting medical conditions such as diabetes, kidney disease, rheumatoid arthritis, lupus, or scleroderma. Pregnancy planning and lifestyle changes may reduce the risk of preeclampsia during pregnancy.
Pregnancy planning is important to help prevent exposure of the mother and fetus to potentially harmful medications and substances during the early days, and throughout the pregnancy. Nutritional planning, prevention of birth defects, conditions such as high blood pressure, heart disease, diabetes, and kidney disease need careful monitoring. Gestational diabetes, preeclampsia, and pregnancy induced hypertension are conditions that may arise during pregnancy. Immunizations, inherited disorders, exercise, air travel, intercourse, and birth control are important factors to consider when planning a pregnancy.
Taking prescription medications or over-the-counter drugs or supplements should be discussed with your doctor. There are some medications that have been found to cause no problems in pregnancy, however, medications such as Accutane for acne, should never be taken during pregnancy.
Women experience and tolerate pain differently. For some pregnant women, focused breathing is all they need to get through labor and childbirth; but for others, numbing of the pain is desired.
There are a number of different medications a woman can take during labor and childbirth. It is important for you to learn what pain relief options are available. Please discuss the options with your health care provider well before your "birth day" so that when you are in labor you understand the choices.
Welcoming baby into the world requires more than making sure he or she is healthy in your tummy. At some point, your little love will make his or her way out of your belly and you need to be prepared. This list should help you get all you need to take care of your baby during the early months. As your baby gets older, you will find other items that will make your life easier.