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- What is pyrimethamine-oral, and how does it work (mechanism of action)?
- What brand names are available for pyrimethamine-oral?
- Is pyrimethamine-oral available as a generic drug?
- Do I need a prescription for pyrimethamine-oral?
- What are the side effects of pyrimethamine-oral?
- What is the dosage for pyrimethamine-oral?
- Which drugs or supplements interact with pyrimethamine-oral?
- Is pyrimethamine-oral safe to take if I'm pregnant or breastfeeding?
- What else should I know about pyrimethamine-oral?
What is the dosage for pyrimethamine-oral?
- Toxoplasmosis treatment For the treatment of toxoplasmosis the recommended adult starting dose is 50 to 75 mg of daily with 1 to 4 g daily of a sulfonamide for 1 to 3 weeks depending on the response of the patient and tolerance to therapy. The dosage of each drug should be reduced by half then continued for an additional 4 to 5 weeks.
- Acute malaria treatment For treatment of acute malaria the dose is 25 to 50 mg daily for 2 days with a sulfonamide though chloroquine or quinine are preferred for treatment of acute malaria.
- Malaria prevention For preventing malaria the recommended dose for adults and children over 10 years of age is 25 mg once weekly, and for children 4 through 10 years of age the dose is 12.5 mg (1/2 tablet) once weekly. Infants and children under 4 years of age should receive 6.25 mg (1/4 tablet) once weekly.
Which drugs or supplements interact with pyrimethamine-oral?
Combining pyrimethamine with other drugs that block folic acid or drugs that suppress the bone marrow may increase the risk of bone marrow suppression. Examples include sulfonamides or trimethoprim-sulfamethoxazole combinations, proguanil, zidovudine (Retrovir), or methotrexate (Trexall). If signs of folate deficiency develop, pyrimethamine should be discontinued and folinic acid (leucovorin) should be administered until normal bone marrow function is restored.
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