pyrimethamine (Daraprim) (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
GENERIC AVAILABLE: No
PREPARATIONS: Tablets: 25 mg.
STORAGE: Pyrimethamine tablets should be stored between 15 C and 25 C (59 F and 77 F).
DRUG INTERACTIONS: Combining pyrimethamine with other drugs that block folic acid or drugs that suppress the bone marrow may increase the risk of bone marrow suppression. Examples include sulfonamides or trimethoprim-sulfamethoxazole combinations, proguanil, zidovudine (Retrovir), or methotrexate (Trexall). If signs of folate deficiency develop, pyrimethamine should be discontinued and folinic acid (leucovorin) should be administered until normal bone marrow function is restored.
PREGNANCY: There are no adequate studies of pyrimethamine in pregnant women. Pyrimethamine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Folic acid should also be given if it is used for the treatment of toxoplasmosis during pregnancy.
NURSING MOTHERS: Pyrimethamine is secreted in breast milk. Women should not nurse while taking pyrimethamine.
REFERENCE: FDA Prescribing Information
Medically Reviewed by a Doctor on 10/12/2015
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