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- What is pyridostigmine-oral, and how does it work (mechanism of action)?
- What brand names are available for pyridostigmine-oral?
- Is pyridostigmine-oral available as a generic drug?
- Do I need a prescription for pyridostigmine-oral?
- What are the side effects of pyridostigmine-oral?
- What is the dosage for pyridostigmine-oral?
- Which drugs or supplements interact with pyridostigmine-oral?
- Is pyridostigmine-oral safe to take if I'm pregnant or breastfeeding?
- What else should I know about pyridostigmine-oral?
What is the dosage for pyridostigmine-oral?
- For the treatment of myasthenia gravis in adults: The dose and frequency of administration must be adjusted to the needs of the individual patient.
- The average dose is ten 60 mg regular release tablets or ten 5-ml teaspoonful (600 mg).
- In individuals with severe disease, as many as 25 doses (1 dose = 60 mg regular release tablet or 5 ml syrup) may be required.
- For in mild disease, 1 to 6 doses may be sufficient.
- If using timespan tablets, one to three 180 mg tablets (180 to 540 mg) once or twice daily usually would be sufficient for providing adequate symptom control. Administration of timespan tablets should be separated by at least 6 hours. To provide coverage for break-thru symptoms, use of more rapidly acting regular tablets or syrup with timespan tablets may be necessary.
- The safety and effectiveness of pyridostigmine use in pediatrics has not been established.
- As pyridostigmine is primarily removed from the body by the kidneys, lower doses may be required in patients with kidney disease.
Which drugs or supplements interact with pyridostigmine-oral?
Pyridostigmine should not be used with other cholinesterase inhibitors such as neostigmine (Bloxiverz, Prostigmin) or edrophonium (Tensilon, Enlon, Reversol) because of the risk of additive toxicity.
Use of quinine (Qualaquin) with pyridostigmine should be avoided as the actions of quinine on skeletal muscle are opposite to those of pyridostigmine.
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