Pycnogenol

Are there any interactions with medications?



Medications for diabetes (Antidiabetes drugs)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Pycnogenol might decrease blood sugar levels. Diabetes medications are also used to lower blood sugar. Taking pycnogenol along with diabetes medications might cause your blood sugar to be too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.

Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), and others. The mechanism of action is unclear.



Medications that decrease the immune system (Immunosuppressants)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Pycnogenol seems to increase the immune system. By increasing the immune system, pycnogenol might decrease the effectiveness of medications that decrease the immune system.

Some medications that decrease the immune system include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and others.



Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Pycnogenol might slow blood clotting. Taking pycnogenol along with medications that also slow clotting might increase the chances of bruising and bleeding.

Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.

Dosing considerations for Pycnogenol.

The following doses have been studied in scientific research:

BY MOUTH:
  • For allergies: 50 mg twice daily.
  • For asthma in children: 1 mg per pound of body weight given in two divided doses.
  • For poor circulation: 45-360 mg daily, or 50-100 mg three times daily.
  • For diseases of the retina, including those related to diabetes: 50 mg three times daily.
  • For mild high blood pressure: 200 mg of pycnogenol daily.
  • For improving exercise capacity in athletes: 200 mg daily.

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