How does Pycnogenol work?

Pycnogenol contains substances that might improve blood flow. It might also stimulate the immune system and have antioxidant effects.

Are there safety concerns?

Pycnogenol might be safe when taken in doses of 120 mg to 450 mg daily for up to 6 months. Larger doses might not be safe. Preliminary clinical research suggests pycnogenol might be safe in late pregnancy, but until more is known, pycnogenol should be avoided by pregnant women. Pycnogenol can cause dizziness, gut problems, headache and mouth ulcers.

Do not take pycnogenol if:
  • You are pregnant or breast-feeding.
  • You have an immune system disease such as multiple sclerosis, systemic lupus erythematosus (SLE), or other auto-immune diseases.

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Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.