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February 10, 2012

Pulmonary Hypertension Glossary of Terms

The following are health and medical definitions of terms that appear in the Pulmonary Hypertension article.

Angina: Chest pain due to an inadequate supply of oxygen to the heart muscle. The chest pain of angina is typically severe and crushing. There is a feeling just behind the breastbone (the sternum) of pressure and suffocation.
See the entire definition of Angina

Apnea: An apnea is a period of time during which breathing stops or is markedly reduced. There are two types of apneas, the more common obstructive sleep apnea and the less common central sleep apnea.
See the entire definition of Apnea

Artery: A vessel that carries blood high in oxygen content away from the heart to the farthest reaches of the body. Since blood in arteries is usually full of oxygen, the hemoglobin in the red blood cells is oxygenated. The resultant form of hemoglobin (oxyhemoglobin) is what makes arterial blood look bright red.
See the entire definition of Artery

Biochemical: Relating to biochemistry, the application of the tools and concepts of chemistry to living systems.
See the entire definition of Biochemical

Blood clot: Blood that has been converted from a liquid to a solid state. Also called a thrombus.
See the entire definition of Blood clot

Blood clots: Blood that has been converted from a liquid to a solid state. Also called a thrombus.
See the entire definition of Blood clots

Blood pressure: The blood pressure is the pressure of the blood within the arteries. It is produced primarily by the contraction of the heart muscle. It's measurement is recorded by two numbers. The first (systolic pressure) is measured after the heart contracts and is highest. The second (diastolic pressure) is measured before the heart contracts and lowest. A blood pressure cuff is used to measure the pressure. Elevation of blood pressure is called "hypertension".

Breathing: The process of respiration, during which air is inhaled into the lungs through the mouth or nose due to muscle contraction, and then exhaled due to muscle relaxation.

Calcium: A mineral found mainly in the hard part of bones, where it is stored. Calcium is added to bones by cells called osteoblasts and is removed from bones by cells called osteoclasts. Calcium is essential for healthy bones. It is also important for muscle contraction, heart action, nervous system maintenance, and normal blood clotting. Food sources of calcium include dairy foods, some leafy green vegetables such as broccoli and collards, canned salmon, clams, oysters, calcium-fortified foods, and tofu. According to the National Academy of Sciences, adequate intake of calcium is 1,200 milligrams a day (four glasses of milk) for men and women 51 and older, 1,000 milligrams a day for adults 19 through 50, and 1,300 milligrams a day for children 9 through 18. The upper limit for calcium intake is 2.5 grams daily.

Learn more about calcium with evidence-based information on RxList.

Carbon dioxide: A gas which is the byproduct of cellular metabolism and which collects in the tissues, is cleared from the tissues by the blood within the veins, is carried by the hemoglobin in the red blood cells, and removed from the body via the lungs in the exhaled air. Abbreviated CO2.

Cardiologist: A doctor who specializes in treating heart disorders.

CAT scan: Pictures of structures within the body created by a computer that takes the data from multiple X-ray images and turns them in pictures on a screen. The CAT (computerized axial tomography) scan can reveal some soft-tissue and other structures that cannot even be seen in conventional X-rays. Using the same dosage of radiation as that of an ordinary X-ray machine, an entire slice of the body can be made visible with about 100 times more clarity with the CAT scan.
See the entire definition of CAT scan

Catheter: A thin, flexible tube. For example, a catheter placed in a vein provides a pathway for giving drugs, nutrients, fluids, or blood products. Samples of blood can also be withdrawn through the catheter.
See the entire definition of Catheter

Chest: The area of the body located between the neck and the abdomen. The chest contains the lungs, the heart and part of the aorta. The walls of the chest are supported by the dorsal vertebrae, the ribs, and the sternum.
See the entire definition of Chest

Chest pain: There are many causes of chest pain. One is angina which results from inadequate oxygen supply to the heart muscle. Angina can be caused by coronary artery disease or spasm of the coronary arteries. Chest pain can also be due to a heart attack (coronary occlusion) and other important diseases such as, for example, dissection of the aorta and a pulmonary embolism. Do not try to ignore chest pain and "work (or play) though it." Chest pain is a warning to seek medical attention.

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Chest X-ray: Commonly used to detect abnormalities in the lungs, but can also detect abnormalities in the heart, aorta, and the bones of the thoracic area. Metallic objects, such as jewelry are removed from the chest and neck areas for a chest x-ray to avoid interference with x-ray penetration and improve accuracy of the interpretation.

Chronic: This important term in medicine comes from the Greek chronos, time and means lasting a long time.
See the entire definition of Chronic

Chronic obstructive pulmonary disease: COPD. Any disorder that persistently obstructs bronchial airflow. COPD mainly involves two related diseases -- chronic bronchitis and emphysema. Both cause chronic obstruction of air flowing through the airways and in and out of the lungs. The obstruction is generally permanent and progresses (becomes worse) over time.
See the entire definition of Chronic obstructive pulmonary disease

Circulation: The movement of fluid in a regular or circuitous course. Although the noun "circulation" does not necessarily refer to the circulation of the blood, for all practical purposes today it does. Heart failure is an example of a problem with the circulation.

Cocaine: The most potent stimulant of natural origin, a bitter addictive anesthetic (pain blocker) which is extracted from the leaves of the coca scrub (Erythroxylon coca) indigenous to the Andean highlands of South America.
See the entire definition of Cocaine

Collagen: Collagen is the principal protein of the skin, tendons, cartilage, bone and connective tissue.

Compress: 1. As a noun, a cloth or another material applied under pressure to an area of the skin and held in place for a period of time. A compress can be any temperature (cold, luke warm, or hot) and it can be dry or wet. It may also be impregnated with medication or, in traditional medicine, an herbal remedy. Most compresses are used to relieve inflammation.
2. As a verb, to squeeze or press together. An injury can compress the spinal cord.

COPD: Chronic obstructive pulmonary disease. Any disorder that persistently obstructs bronchial airflow. COPD mainly involves two related diseases -- chronic bronchitis and emphysema. Both cause chronic obstruction of air flowing through the airways and in and out of the lungs. The obstruction is generally permanent and progresses (becomes worse) over time.
See the entire definition of COPD

Cough: A rapid expulsion of air from the lungs typically in order to clear the lung airways of fluids, mucus, or material. Also called tussis.

Cure: 1. To heal, to make well, to restore to good health. Cures are easy to claim and, all too often, difficult to confirm.
2. A time without recurrence of a disease so that the risk of recurrence is small, as in the 5-year cure rate for malignant melanoma.
3. Particularly in the past, a course of treatment. For example, take a cure at a spa.
See the entire definition of Cure

Dexfenfluramine: A weight loss drug, in a class of drugs called anorectics which decrease appetite. This drug, sold in the US under the brand name Redux, was withdrawn from the US market in 1997, and has since been withdrawn worldwide and is no longer available because of its association with abnormal heart valve findings, primarily aortic regurgitation.

Diagnosis: 1 The nature of a disease; the identification of an illness. 2 A conclusion or decision reached by diagnosis. The diagnosis is rabies. 3 The identification of any problem. The diagnosis was a plugged IV.
See the entire definition of Diagnosis

Diastolic: Referring to the time when the heart is in a period of relaxation and dilatation (expansion).
See the entire definition of Diastolic

Dilating: The widening and opening of the cervix caused by uterine contractions.

Dizziness: Painless head discomfort with many possible causes including disturbances of vision, the brain, balance (vestibular) system of the inner ear, and gastrointestinal system. Dizziness is a medically indistinct term which laypersons use to describe a variety of conditions ranging from lightheadedness, unsteadiness to vertigo.
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Dysfunction: Difficult function or abnormal function.
See the entire definition of Dysfunction

ECG: Abbreviation for electrocardiogram or EKG. The K is from "kardio" (in German).

Electrocardiogram: A recording of the electrical activity of the heart. An electrocardiogram is a simple, non-invasive procedure. Electrodes are placed on the skin of the chest and connected in a specific order to a machine that, when turned on, measures electrical activity all overaround the heart. Output is usually in the form of a long scroll of paper displaying a printed graph of activity. Newer models output the data directly to a computer and screen, although a print-out may still be made.
See the entire definition of Electrocardiogram

Emboli: Something that travels through the bloodstream, lodges in a blood vessel and blocks it. Examples of emboli are a detached blood clot, a clump of bacteria, and foreign material such as air.
See the entire definition of Emboli

Endothelium: A layer of flat cells lining the closed internal spaces of the body such as the inside of blood vessels and lymphatic vessels (that convey the lymph, a milky fluid) and the heart.
See the entire definition of Endothelium

Erectile dysfunction: A common men's health problem characterized by the consistent inability to sustain an erection sufficient for sexual intercourse or the inability to achieve ejaculation, or both. Impotence can vary. It can involve a total inability to achieve an erection or ejaculation, an inconsistent ability to do so, or a tendency to sustain only very brief erections. Erectile dysfunction is also called impotence,
See the entire definition of Erectile dysfunction

Familial: A condition that is tends to occur more often in family members than expected by chance alone. A familial disease may be genetic (such as cystic fibrosis) or environmental (such as tuberculosis).

Fatigue: A condition characterized by a lessened capacity for work and reduced efficiency of accomplishment, usually accompanied by a feeling of weariness and tiredness. Fatigue can be acute and come on suddenly or chronic and persist.
See the entire definition of Fatigue

Femoral: Having to do with the femur or, less often, the thigh. As in the femoral head (the head of the femur), the femoral artery, and femoral vein.

Femoral vein: The largest vein in the groin. The femoral vein is a continuation of the popliteal vein. It passes, together with the femoral artery, beneath the inguinal ligament to enter the abdomen and form the external iliac vein. The femoral vein is one portion of the venous system that carries blood from the lower extremity back to the heart.
See the entire definition of Femoral vein

Gene: The basic biological unit of heredity. A segment of deoxyribonucleic acid (DNA) needed to contribute to a function.
See the entire definition of Gene

Genetic: Having to do with genes and genetic information.

Glycogen storage disease: One of the 14 recognized diseases that interfere with the storage of carbohydrates as glycogen in the body. See also: McArdle disease.

Groin: In anatomy, the area where the upper thigh meets the trunk. More precisely, the fold or depression marking the juncture of the lower abdomen and the inner part of the thigh.
See the entire definition of Groin

Heart: The muscle that pumps blood received from veins into arteries throughout the body. It is positioned in the chest behind the sternum (breastbone; in front of the trachea, esophagus, and aorta; and above the diaphragm muscle that separates the chest and abdominal cavities. The normal heart is about the size of a closed fist, and weighs about 10.5 ounces. It is cone-shaped, with the point of the cone pointing down to the left. Two-thirds of the heart lies in the left side of the chest with the balance in the right chest.
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Heart disease: Any disorder that affects the heart. Sometimes the term "heart disease" is used narrowly and incorrectly as a synonym for coronary artery disease. Heart disease is synonymous with cardiac disease but not with cardiovascular disease which is any disease of the heart or blood vessels. Among the many types of heart disease, see, for example: Angina; Arrhythmia; Congenital heart disease; Coronary artery disease (CAD); Dilated cardiomyopathy; Heart attack (myocardial infarction); Heart failure; Hypertrophic cardiomyopathy; Mitral regurgitation; Mitral valve prolapse; and Pulmonary stenosis.

Heart failure: Inability of the heart to keep up with the demands on it and, specifically, failure of the heart to pump blood with normal efficiency. When this occurs, the heart is unable to provide adequate blood flow to other organs such as the brain, liver and kidneys. Heart failure may be due to failure of the right or left or both ventricles. The signs and symptoms depend upon which side of the heart is failing. They can include shortness of breath (dyspnea), asthma due to the heart (cardiac asthma), pooling of blood (stasis) in the general body (systemic) circulation or in the liver's (portal) circulation, swelling (edema), blueness or duskiness (cyanosis), and enlargement (hypertrophy) of the heart.
See the entire definition of Heart failure

Heart muscle: A type of muscle with unique features only found in the heart. The heart muscle, or cardiac muscle, is medically called the myocardium ("myo-" being the prefix denoting muscle).

High altitude: Altitude sickness occurs at high altitude. So what is high altitude?
See the entire definition of High altitude

HIV: Acronym for the Human Immunodeficiency Virus, the cause of AIDS (acquired immunodeficiency syndrome). HIV has also been called the human lymphotropic virus type III, the lymphadenopathy-associated virus and the lymphadenopathy virus. No matter what name is applied, it is a retrovirus. (A retrovirus has an RNA genome and a reverse transcriptase enzyme. Using the reverse transcriptase, the virus uses its RNA as a template for making complementary DNA which can integrate into the DNA of the host organism).
See the entire definition of HIV

Hypertension: High blood pressure, defined as a repeatedly elevated blood pressure exceeding 140 over 90 mmHg -- a systolic pressure above 140 with a diastolic pressure above 90.
See the entire definition of Hypertension

Hypoxia: A subnormal concentration of oxygen. By contrast with normoxia (normal oxygen) and anoxia (the absence or near absence of oxygen). From hyp- (below) + -ox- (oxygen) + -ia.

Hypoxic: Pertaining to hypoxia, a subnormal concentration of oxygen.

Idiopathic: Of unknown cause. Any disease that is of uncertain or unknown origin may be termed idiopathic. For example, acute idiopathic polyneuritis, diffuse idiopathic skeletal hyperostosis, idiopathic pulmonary fibrosis, idiopathic scoliosis, etc.
See the entire definition of Idiopathic

Indicate: In medicine, to make a treatment or procedure advisable because of a particular condition or circumstance. For example, certain medications are indicated for the treatment of hypertension during pregnancy while others are contraindicated.

Infection: The growth of a parasitic organism within the body. (A parasitic organism is one that lives on or in another organism and draws its nourishment therefrom.) A person with an infection has another organism (a "germ") growing within him, drawing its nourishment from the person.
See the entire definition of Infection

Kidney: One of a pair of organs located in the right and left side of the abdomen which clear "poisons" from the blood, regulate acid concentration and maintain water balance in the body by excreting urine. The kidneys are part of the urinary tract. The urine then passes through connecting tubes called "ureters" into the bladder. The bladder stores the urine until it is released during urination.


See the entire definition of Kidney

Left heart: The heart is composed functionally of two hearts - the right heart and the left heart. The left heart consists of the left atrium which receives oxygenated blood from the lung and the left ventricle which pumps it out to the body under high pressure.

Left ventricle: The left lower chamber of the heart that receives blood from the left atrium and pumps it out under high pressure through the aorta to the body.

Lethargy: 1. Abnormal drowsiness, stupor. 2. A state of indifference.
From the Greek lethargia, drowsiness.

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Liver: An organ in the upper abdomen that aids in digestion and removes waste products and worn-out cells from the blood. The liver is the largest solid organ in the body. The liver weighs about three and a half pounds (1.6 kilograms). It measures about 8 inches (20 cm) horizontally (across) and 6.5 inches (17 cm) vertically (down) and is 4.5 inches (12 cm) thick.


See the entire definition of Liver

Liver disease: Liver disease refers to any disorder of the liver. The liver is a large organ in the upper right abdomen that aids in digestion and removes waste products from the blood.
See the entire definition of Liver disease

Lumen: A luminous term referring to the channel within a tube such as a blood vessel or to the cavity within a hollow organ such as the intestine. Lumen is a luminous term because it is Latin for light, including the light that comes through a window. When a hollow organ is cut across, you can see light through the space that has been opened. So the word "lumen" came to mean this space.
See the entire definition of Lumen

Lungs: The lungs are a pair of breathing organs located with the chest which remove carbon dioxide from and bring oxygen to the blood. There is a right and left lung.

Metabolic: Relating to metabolism, the whole range of biochemical processes that occur within us (or any living organism). Metabolism consists of anabolism (the buildup of substances) and catabolism (the breakdown of substances).
See the entire definition of Metabolic

Mouth: 1. The upper opening of the digestive tract, beginning with the lips and containing the teeth, gums, and tongue. Foodstuffs are broken down mechanically in the mouth by chewing and saliva is added as a lubricant. Saliva contains amylase, an enzyme that digests starch. 2. Any opening or aperture in the body. The mouth in both senses of the word is also called the os, the Latin word for an opening, or mouth. The o in os is pronounced as in hope. The genitive form of os is oris from which comes the word oral.

Multifactorial: Multiple factors.
See the entire definition of Multifactorial

Muscle: Muscle is the tissue of the body which primarily functions as a source of power. There are three types of muscle in the body. Muscle which is responsible for moving extremities and external areas of the body is called "skeletal muscle." Heart muscle is called "cardiac muscle." Muscle that is in the walls of arteries and bowel is called "smooth muscle."

Nurse: 1) A person trained, licensed, or skilled in nursing. 2) To feed an infant at the breast.

Obstruction: Blockage of a passageway. See, for example: Airway obstruction; Intestinal obstruction.

Onset: In medicine, the first appearance of the signs or symptoms of an illness as, for example, the onset of rheumatoid arthritis. There is always an onset to a disease but never to the return to good health. The default setting is good health.
See the entire definition of Onset

Oxygen: A colorless, odorless and tasteless gas that makes up about 20% of the air we breathe (and at least half the weight of the entire solid crust of the earth) and which combines with most of the other elements to form oxides. Oxygen is essential to human, animal and plant life.
See the entire definition of Oxygen

Pain: An unpleasant sensation that can range from mild, localized discomfort to agony. Pain has both physical and emotional components. The physical part of pain results from nerve stimulation. Pain may be contained to a discrete area, as in an injury, or it can be more diffuse, as in disorders like fibromyalgia. Pain is mediated by specific nerve fibers that carry the pain impulses to the brain where their conscious appreciation may be modified by many factors.
See the entire definition of Pain

Parasitic: Having to do with a parasite, as in a parasitic infection; or acting like a parasite by taking nourishment from another.

Pneumonia: Inflammation of one or both lungs with consolidation. Pneumonia is frequently but not always due to infection. The infection may be bacterial, viral, fungal or parasitic. Symptoms may include fever, chills, cough with sputum production, chest pain, and shortness of breath.

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Prevalence: The proportion of individuals in a population having a disease. Prevalence is a statistical concept referring to the number of cases of a disease that are present in a particular population at a given time.

Prognosis: 1. The expected course of a disease.
2. The patient's chance of recovery.
The prognosis predicts the outcome of a disease and therefore the future for the patient. His prognosis is grim, for example, while hers is good.
See the entire definition of Prognosis

Pulmonary: Having to do with the lungs. (The word comes from the Latin pulmo for lung).

Pulmonary arterial hypertension: See: Pulmonary hypertension.

Pulmonary artery: One of the two vessels which are formed as terminal branches of the pulmonary trunk and convey unaerated blood to the lungs. The two pulmonary arteries differ in length and anatomy.
See the entire definition of Pulmonary artery

Pulmonary fibrosis: Scarring throughout the lungs which can be caused by many conditions such as, sarcoidosis, hypersensitivity pneumonitis, asbestosis, and certain medications. Pulmonary fibrosis can also occur without an identifiable cause, in which case it is referred to as idiopathic pulmonary fibrosis. Symptoms include shortness of breath, coughing and diminished exercise tolerance. Treatment involves the use of corticosteroids (such as prednisone) and/or other medications that suppress the body's immune system. Interferon gamma-1b treatment may help patients with idiopathic pulmonary fibrosis who do not respond to corticosteroid therapy. The goal of treatment is to decrease lung inflammation and subsequent scarring. Responses to treatment vary. Toxicity and side effects of treatments can be serious. Therefore, patients with pulmonary fibrosis are generally cared for by lung specialists.
See the entire definition of Pulmonary fibrosis

Pulmonary hypertension: High blood pressure in the pulmonary artery that conveys blood from the right ventricle to the lungs. The pressure in the pulmonary artery is normally low compared to that in the aorta. Pulmonary hypertension can irrevocably damage the lungs and cause failure of the right ventricle.
See the entire definition of Pulmonary hypertension

Receptor: 1. In cell biology, a structure on the surface of a cell (or inside a cell) that selectively receives and binds a specific substance. There are many receptors. There is a receptor for (insulin; there is a receptor for low-density lipoproteins (LDL); etc. To take an example, the receptor for substance P, a molecule that acts as a messenger for the sensation of pain, is a unique harbor on the cell surface where substance P docks. Without this receptor, substance P cannot dock and cannot deliver its message of pain. Variant forms of nuclear hormone receptors mediate processes such as cholesterol metabolism and fatty acid production. Some hormone receptors are implicated in diseases such as diabetes and certain types of cancer. A receptor called PXR appears to jump-start the body's response to unfamiliar chemicals and may be involved in drug-drug interactions.
2. In neurology, a terminal of a sensory nerve that receives and responds to stimuli.

Recurrent: Back again. A recurrent fever is a fever that has returned after an intermission: a recrudescent fever.

Redux: See: Dexfenfluramine.

Referral: The recommendation of a medical or paramedical professional. If you get a referral to ophthalmology, for example, you are being sent to the eye doctor. In HMOs and other managed care schemes, a referral is usually necessary to see any practitioner or specialist other than your primary care physician (PCP), if you want the service to be covered. The referral is obtained from your PCP, who may require a telephone or office consultation first.
See the entire definition of Referral

Resistance: Opposition to something, or the ability to withstand it. For example, some forms of staphylococcus are resistant to treatment with antibiotics.

Rheumatologist: A specialist in the non-surgical treatment of rheumatic illnesses, especially arthritis.
See the entire definition of Rheumatologist

Right heart: The heart is composed functionally of two hearts - the right heart and the left heart. The right heart consists of the right atrium which receives deoxygenated blood from the body and the right ventricle which pumps it to the lungs. The right heart is a low pressure system.

Right ventricle: The lower right chamber of the heart that receives deoxygenated blood from the right atrium and pumps it under low pressure into the lungs via the pulmonary artery.
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Sarcoidosis: A disease of unknown origin that causes small lumps (granulomas) due to chronic inflammation to develop in a great range of body tissues. Sarcoidosis can appear in almost any body organ, but most often starts in the lungs or lymph nodes. It also affects the eyes, liver and skin; and less often the spleen, bones, joints, skeletal muscles, heart and central nervous system (brain and spinal cord).
See the entire definition of Sarcoidosis

Scan: As a noun, the data or image obtained from the examination of organs or regions of the body by gathering information with a sensing device.
See the entire definition of Scan

Schistosomiasis: Diseases of liver, gastrointestinal tract and bladder caused by schistosomes, trematode worms that parasitize people. Infection is from infested water.
See the entire definition of Schistosomiasis

Scleroderma: A disease of connective tissue with the formation of scar tissue (fibrosis) in the skin and sometimes also in other organs of the body.
See the entire definition of Scleroderma

Shortness of breath: Difficulty in breathing. Medically referred to as dyspnea. Shortness of breath can be caused by respiratory (breathing passages and lungs) or circulatory (heart and blood vessels) conditions. See also dyspnea.

Sleep: The body's rest cycle.
See the entire definition of Sleep

Sleep apnea: The temporary stoppage of breathing during sleep, often resulting in daytime sleepiness. Apnea is a Greek word that means "want of breath."
See the entire definition of Sleep apnea

Smooth muscle: One of the three types of muscle tissue in the body (skeletal, smooth, cardiac). Generally forms the supporting tissue of blood vessels and hollow internal organs such as the stomach, intestine, and bladder. So named because of the absence of microscopic lines called "cross-striations" which are seen in the other two types.

Sporadic: Occurring upon occasion or in a scattered, isolated or seemingly random way.
See the entire definition of Sporadic

Stress: Forces from the outside world impinging on the individual. Stress is a normal part of life that can help us learn and grow. Conversely, stress can cause us significant problems.
See the entire definition of Stress

Subclavian: Under the clavicle (the collar bone), as the subclavian artery or the subclavian vein.

Systemic: Affecting the entire body. A systemic disease such as diabetes can affect the whole body. Systemic chemotherapy employs drugs that travel through the bloodstream and reach and affect cells all over the body.

Systolic: The blood pressure when the heart is contracting. It is specifically the maximum arterial pressure during contraction of the left ventricle of the heart. The time at which ventricular contraction occurs is called systole.
See the entire definition of Systolic

Therapy: The treatment of disease.
See the entire definition of Therapy

Thrombosis: The formation or presence of a blood clot in a blood vessel. The vessel may be any vein or artery as, for example, in a deep vein thrombosis or a coronary (artery) thrombosis. The clot itself is termed a thrombus. If the clot breaks loose and travels through the bloodstream, it is a thromboembolism. Thrombosis, thrombus, and the prefix thrombo- all come from the Greek thrombos meaning a lump or clump, or a curd or clot of milk. See entries also to: Cavernous sinus thrombosis; Renal vein thrombosis. And see: Deep Vein Thrombosis and Pulmonary Embolism.

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Toxin: One of a number of poisons produced by certain plants, animals, and bacteria.
See the entire definition of Toxin

Transforming growth factor: (TGF) One of several proteins secreted by transformed cells that can stimulate the growth of normal cells. Transforming growth factor alpha (TGF alpha or TGF-A) binds the epidermal growth factor receptor (EGFR) and stimulates the growth of endothelial cells (cells that line the inside of blood vessels). Transforming growth factor beta (TGF-beta or TGF-B) is found in hematopoietic (blood-forming) tissue and initiates a signaling pathway that suppresses the early development of cancer cells.

Transplant: The grafting of a tissue from one place to another, just as in botany a bud from one plant might be grafted onto the stem of another. The transplanting of tissue can be from one part of the patient to another (autologous transplantation), as in the case of a skin graft using the patient's own skin; or from one patient to another (allogenic transplantation), as in the case of transplanting a donor kidney into a recipient.

Tumor: An abnormal mass of tissue. Tumors are a classic sign of inflammation, and can be benign or malignant (cancerous). There are dozens of different types of tumors. Their names usually reflect the kind of tissue they arise in, and may also tell you something about their shape or how they grow. For example, a medulloblastoma is a tumor that arises from embryonic cells (a blastoma) in the inner part of the brain (the medulla). Diagnosis depends on the type and location of the tumor. Tumor marker tests and imaging may be used; some tumors can be seen (for example, tumors on the exterior of the skin) or felt (palpated with the hands).
See the entire definition of Tumor

Ultrasound: High-frequency sound waves. Ultrasound waves can be bounced off of tissues using special devices. The echoes are then converted into a picture called a sonogram. Ultrasound imaging, referred to as ultrasonography, allows physicians and patients to get an inside view of soft tissues and body cavities, without using invasive techniques. Ultrasound is often used to examine a fetus during pregnancy. There is no convincing evidence for any danger from ultrasound during pregnancy.

Vascular: Relating to the blood vessels of the body. The blood vessels of the body, as a group, are referred to as the vascular system.
See the entire definition of Vascular

Vasoconstriction: Narrowing of the blood vessels resulting from contracting of the muscular wall of the vessels. The opposite of vasodilation.

Vein: A blood vessel that carries blood low in oxygen content from the body back to the heart. The deoxygenated form of hemoglobin (deoxyhemoglobin) in venous blood makes it appear dark. Veins are part of the afferent wing of the circulatory system which returns blood to the heart.
See the entire definition of Vein

Ventricle: A chamber of an organ. For example, the four connected cavities (hollow spaces) in the central portion of the brain and the lower two chambers of the heart are called ventricles.

Ventricular: Pertaining to the ventricles, the lower chambers of the heart, as in ventricular fibrillation and ventricular septal defect.

Vessel: A tube in the body that carries fluids: blood vessels or lymph vessels.

X-ray: 1. High-energy radiation with waves shorter than those of visible light. X-rays possess the properties of penetrating most substances (to varying extents), of acting on a photographic film or plate (permitting radiography), and of causing a fluorescent screen to give off light (permitting fluoroscopy). In low doses X-rays are used for making images that help to diagnose disease, and in high doses to treat cancer. Formerly called a Roentgen ray. 2. An image obtained by means of X-rays.

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      • Fainting, also referred to as blacking out, syncope, or temporary loss of consciousness has many causes. Often a person will have signs or symptoms prior to the fainting episode. Diagnosis and treatment depends upon the cause of the fainting or syncope episode.
    • Sarcoidosis
      • Sarcoidosis, a disease resulting from chronic inflammation, causes small lumps (granulomas) to develop in a great range of body tissues and can appear in almost any body organ. However, sarcoidosis most often starts in the lungs or lymph nodes.
    • Sleep Apnea
      • Sleep apnea is defined as a reduction or cessation of breathing during sleep. The three types of sleep apnea are central apnea, obstructive apnea (OSA), and a mixture of central and obstructive apnea. Central sleep apnea is caused by a failure of the brain to activate the muscles of breathing during sleep. OSA is caused by the collapse of the airway during sleep. OSA is diagnosed and evaluated through patient history, physical examination and polysomnography. There are many complications related to obstructive sleep apnea. Treatments are surgical and non-surgical.
    • Chest Pain
      • Chest pain is a common complaint by a patient in the ER. Causes of chest pain include broken or bruised ribs, pleurisy, pneumothorax, shingles, pneumonia, pulmonary embolism, angina, heart attack, costochondritis, pericarditis, aorta or aortic dissection, and reflux esophagitis. Diagnosis and treatment of chest pain depends upon the cause and clinical presentation of the patient's chest pain.
    • Chronic Obstructive Pulmonary Disease
      • COPD (chronic obstructive pulmonary disease) is a disorder that persistently obstructs bronchial airflow. COPD mainly involves three related conditions, chronic bronchitis, chronic asthma, and emphysema. Symptoms of COPD include chronic cough, shortness of breath, frequent respiratory infections, wheezing, morning headaches, and pulmonary hypertension. Treatment of COPD is focused on the related condition(s).
    • Scleroderma
      • Scleroderma is an autoimmune disease of the connective tissue. It is characterized by the formation of scar tissue (fibrosis) in the skin and organs of the body, leading to thickness and firmness of involved areas. Scleroderma is also referred to as systemic sclerosis, and the cause is unknown. Treatment of scleroderma is directed toward the individual features that are most troubling to the patient.
    • Emphysema
      • Emphysema is a progressive disease of the lungs. The primary cause of emphysema is smoking. Alpha 1-antitrypsin deficiency is a rare disorder that has a genetic predisposition to emphysema. Aging, IV drug use, immune deficiencies, and connect tissue illnesses are also risk factors for emphysema. Emphysema is a subtype of COPD (chronic obstructive pulmonary disease, COLD). Symptoms include shortness of breath and wheezing. Management of symptoms may be achieved with medications, quitting smoking, pulmonary rehabilitation, or surgery.
    • Polycythemia (High Red Blood Cell Count)
      • Polycythemia (elevated red blood cell count) causes are either primary (aquired or genetic mutations) or secondary (diseases, conditions, high altitude). Treatment of polycythemia depends on the cause.
    • Pulmonary Fibrosis
      • Pulmonary fibrosis is scarring throughout the lungs. Pulmonary fibrosis can be caused by many conditions including chronic inflammatory processes, infections, environmental agents, exposure to ionizing radiation, chronic conditions, and certain medications. Symptoms include shortness of breath, coughing, and diminished exercise tolerance. Treatment options are dependent on the type of pulmonary fibrosis; lung transplant and/or medications are optons.
    • Heart Disease
      • Heart disease (coronary artery disease) is caused by a buildup of cholesterol deposits in the coronary arteries. Risk factors for heart disease include smoking, high blood pressure, heredity, diabetes, peripheral artery disease, and obesity. Symptoms include chest pain and shortness of breath. There are a variety of tests used to diagnose coronary artery disease. Treatment includes life-style changes, medications, procedures, or surgery.
    • Obesity
      • Obesity is the state of being well above one's normal weight. A person has traditionally been considered to be obese if they are more than 20 percent over their ideal weight. That ideal weight must take into account the person's height, age, sex, and build.
    • High Blood Pressure Treatment
      • High blood pressure (hypertension) means high pressure (tension) in the arteries. Treatment for high blood pressure include lifestyle modifications (alcohol, smoking, coffee, salt, diet, exercise), drugs and medications such as ACE inhibitors, angiotensin receptor blockers, beta blockers, diuretics, calcium channel blockers (CCBs), alpha blockers, clonidine, minoxidil, and Exforge.
    • Interstitial Lung Disease
      • Interstitial lung disease, is a term to describe a certain lung condition. Causes of interstitial lung disease include lung infection, exposure to toxins in the environment (asbestos for example), medications (chemotherapy), radiation therapy, and chronic autoimmune disorders. Common symptoms of interstitial lung disease include a dry cough and shortness of breath. Diagnosis and treatment depend upon the cause of the condition.
    • Bronchiectasis
      • Bronchiectasis is a condition in which the bronchial tubes of the lung become damaged. Inflammation from infection or other causes destroys the smooth muscles of the bronchial tubes. Bronchiectasis is a form of COPD (which includes emphysema and chronic bronchitis). There are three primary types of bronchiectasis: 1) cylindrical bronchiectasis; 2) saccular bronchiectasis; and 3) cystic bronchiectasis. Bronchiectasis may also be acquired or congenital. The most common symptoms of bronchiectasis are recurrent cough and sputum production. There is no cure for bronchiectasis. Treatment is often geared toward controlling the symptoms of bronchiectasis.
    • Ventricular Septal Defect
      • A ventricular septal defect (VSD) is a congenital heart malformation. A VSD is a hole in the wall of the heart's two lower chambers. Approximately, one in 500 infants will be born with a VSD. Treatment depends upon whether the VSD is small or large in size.
    • Schistosomiasis
      • Schistosomiasis (snail fever), a disease caused by parasites, causes a variety of symptoms and signs, such as cough, rash and bloody diarrhea. Praziquantel is used in the treatment of schistosomiasis.
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Pulmonary Hypertension

What is schistosomiasis?

Schistosomiasis is a disease that is caused by parasites (genus Schistosoma) that enter humans by attaching to the skin, penetrating it, and then migrating through the venous system to the portal veins where the parasites produce eggs and eventually, the symptoms of acute or chronic disease (for example, fever, abdominal discomfort, blood in stools). This disease is also known as bilharziasis, bilharzia, bilharziosis, and snail fever or, in the acute form, Katayama fever. Theodore Bilharz identified the parasite Schistosoma hematobium in Egypt in 1851. Schistosomiasis is the second most prevalent tropical disease in the world; malaria is the first. The disease is found mainly in developing countries in Africa, Asia, South America, the Middle East, and the Caribbean. About 207 million people in at least 74 countries are estimated to have the disease. In the U.S., it is diagnosed in tourists who have visited these developing...

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