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February 10, 2012

Pulmonary Embolism (cont.)

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Thrombolytic therapy

Pulmonary embolism can be fatal, especially if involves a large amount of clot. When the patient is unconscious, has low or no blood pressure or are not breathing, clot busting or thrombolytic therapy using medications like TPA (tissue plasminogen activator) may be considered. It is also often considered when signs of right heart strain are present. Some physicians argue that thrombolytic therapy should be used more often, since the source clot is also dissolved as well as the pulmonary embolus. This therapy is associated with a slightly greater risk of bleeding and is contraindicated if recent surgery or significant trauma has occurred.

What is the prognosis for pulmonary embolism?

Patient survival depends upon:

  • the underlying health of the patient,

  • size of the pulmonary embolus,

  • the cause of the pulmonary embolus, and

  • the ability for a diagnosis to be made and treatment initiated.

The diagnosis is often difficult, and it is estimated to that there are up to 400,000 cases of pulmonary embolus that are not diagnosed in the United States each year.

In those patients where the diagnosis is made, the mortality rate is less than 20% when considering all patients. Usually, however, the mortality risk is much less in most patients. The higher incidence of death occurs in patients that are older, have other underlying illnesses, or have a delay in diagnosis. Racial differences may also exist, but probably are due more to access to quality care than a specific genetic difference.

How can pulmonary embolism be prevented?

As mentioned earlier, minimizing the risk of deep vein thrombosis is key in preventing a potentially lethal illness.

  • In the hospital setting, the staff works hard to minimize the potential for clot formation in immobilized patients. Compression stockings are routinely used. Surgery patients are out of bed walking (ambulatory) earlier and low dose heparin or enoxaparin is being used for deep vein thrombosis prophylaxis (measures taken to prevent deep vein thrombosis).

  • For those who travel, it is recommended that they get up and walk every couple of hours during a long trip.

  • Compression stockings may be helpful in preventing future deep vein thrombus formation in patients with a previous history of a clot.

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