pseudoephedrine (Oral, Afrinol, Sudafed) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:


  • The recommended dose is 60 mg every 4 to 6 hours when using immediate release tablets. When using extended release tablets the recommended dose is 120 mg every 12 hours or 240 mg every 24 hours.


  • Pseudoephedrine should not be combined with monoamine oxidase inhibitors (MAOIs) because such combinations may cause an acute hypertensive episode. Examples of MAOIs include rasagiline (Azilect), selegiline (Eldepryl, Zelapar), isocarboxazid (Marplan), phenelzine (Nardil), and tranylcypromine (Parnate).


  • Use of pseudoephedrine by pregnant women has not been adequately evaluated.
  • Pseudoephedrine is secreted in breast milk. However, it is considered safe to use while nursing.


  • Tablet (immediate-release): 30, 60 mg; Tablet (extended-release): 120, 240 mg


  • Pseudoephedrine is a decongestant used for reducing nasal congestion caused by allergies or the common cold. Pseudoephedrine causes blood vessels in the nasal passages to shrink (vasoconstrict). Vasoconstriction reduces nasal congestion by preventing fluid from draining from blood vessels into nasal passages. Pseudoephedrine also directly stimulates beta-adrenergic receptors and causes relaxation of bronchioles, as well as increased heart rate and contractility.
  • The FDA approved pseudoephedrine in August 1975.

REFERENCE: FDA Prescribing Information.

Medically Reviewed by a Doctor on 1/11/2016

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Pill Finder Tool

Need help identifying pills and medications?
Use the pill identifier tool on RxList.

Back to Medications Index

Health Solutions From Our Sponsors