Ablation: Removal or excision. Ablation is usually carried out surgically. For example, surgical removal of the thyroid gland (a total thyroidectomy) is ablation of the thyroid. The word ablation comes from the Latin ablatum meaning to carry away. See the entire definition of Ablation
Cancer: An abnormal growth of cells which tend to proliferate in an uncontrolled way and, in some cases, to metastasize (spread). See the entire definition of Cancer
Carcinoma:Cancer that begins in the skin or in tissues that line or cover body organs. For example, carcinoma can arise in the breast, colon, liver, lung, prostate, and stomach.
Cast: 1) A protective shell of fiberglass, plastic, or plaster, and bandage that is molded to protect broken or fractured limb(s) as it heals. 2) An abnormal mass of dead cells that forms in a body cavity. For example, cases of cells that form in the tubules of the kidneys are sometimes detected in urine samples.
Chemoembolization:Chemoembolization is a procedure in which the blood supply to a tumor is blocked and anticancer drugs are administered directly into the tumor, permitting a much higher concentration of drugs to be in contact with the tumor for a longer period of time, while depriving the tumor of oxygen and nutrients. The procedure is used to treat cancer originating in the liver (primary liver cancer) as well as cancer that has metastasized (spread) to the liver from another area.
Hepatocellular carcinoma: A tumor in which the cancer starts during adulthood in cells in the liver. Also called adult primary liver cancer. See the entire definition of Hepatocellular carcinoma
Lesion: Pronounced "lee-sion" with the emphasis on the "lee," a lesion can be almost any abnormality involving any tissue or organ due to any disease or any injury. See the entire definition of Lesion
Liver: An organ in the upper abdomen that aids in digestion and removes waste products and worn-out cells from the blood. The liver is the largest solid organ in the body. The liver weighs about three and a half pounds (1.6 kilograms). It measures about 8 inches (20 cm) horizontally (across) and 6.5 inches (17 cm) vertically (down) and is 4.5 inches (12 cm) thick.
Radiation:1. Rays of energy. Gamma rays and X-rays are two of the types of energy waves often used in medicine. 2. The use of energy waves to diagnose or treat disease. See also: Irradiation.
TACE: Transarterial chemoembolization, a procedure in which the blood supply to a tumor is blocked (embolized) and chemotherapy is administered directly into the tumor. Used to treat liver cancer.
Tumor: An abnormal mass of tissue. Tumors are a classic sign of inflammation, and can be benign or malignant (cancerous). There are dozens of different types of tumors. Their names usually reflect the kind of tissue they arise in, and may also tell you something about their shape or how they grow. For example, a medulloblastoma is a tumor that arises from embryonic cells (a blastoma) in the inner part of the brain (the medulla). Diagnosis depends on the type and location of the tumor. Tumor marker tests and imaging may be used; some tumors can be seen (for example, tumors on the exterior of the skin) or felt (palpated with the hands). See the entire definition of Tumor
Liver cancer is the fifth most common cancer in the world and the majority of patients with liver cancer will die within one year as a result. Patients with associated cirrhosis caused by chronic hepatitis B or C infections, alcohol, and hemochromatosis are at the greatest risk of developing liver cancer. Many patients with liver cancer do not develop symptoms until the advanced stages of the tumor which usually makes prognosis poor. The combination of an imaging study (ultrasound, CT, or MRI scans) and an elevated blood level of alpha-fetoprotein will most effectively diagnose liver cancer, while a liver biopsy can make a definitive diagnosis. Medical treatments, including chemotherapy, chemoembolization, ablation, and proton beam therapy, are not very effective. Surgical removal of the tumor or a liver transplant may be most effective in certain cases.
When do surgeons do radiofrequency ablation (RFA)?
In the U.S., radiofrequency ablation (RFA) therapy has become the ablation (tissue destruction) therapy
of choice among surgeons for treating liver cancer (HCC). The surgeon can
perform this procedure laparoscopically (through small holes in the abdomen) or
during open exploration of the abdomen. In some instances, the procedure can be
done without opening the abdomen by just using ultrasound for visual
guidance.
How is RFA done and how does it
work?
In RFA, heat is generated locally by a high frequency, alternating current
that flows from the electrodes. A probe is inserted into the center of the tumor
and the non-insulated electrodes, which are shaped like prongs, are projected
into the tumor. The local heat that is generated melts the tissue (coagulative
necrosis) that is adjacent to the probe. The probe is left in place for about 10
to 15 minutes. The whole procedur...
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