Proton Pump Inhibitors (PPIs) (cont.)

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Medical and Pharmacy Editor:

With which drugs do proton pump inhibitors (PPIs) interact?

Proton pump inhibitors interact with few drugs. The absorption into the body of some drugs is affected by the presence of acid in the stomach, and because PPIs reduce acid in the stomach, they may affect the absorption of these drugs. Specifically, PPIs reduce the absorption and concentration in the blood of ketoconazole (Nizoral) and increase the absorption and concentration of digoxin (Lanoxin). This may lead to reduced effectiveness of ketoconazole and an increase in digoxin toxicity.

Proton pump inhibitors can reduce the break-down of some drugs by the liver and lead to an increase in their concentration in the blood. Omeprazole (Prilosec) is more likely than the other PPIs to reduce the break-down of drugs by the liver. For example, omeprazole (Prilosec) may increase the concentration in the blood of diazepam (Valium), warfarin (Coumadin) and phenytoin (Dilantin).

Omeprazole (Prilosec, Prilosec OTC) reduces the effect of clopidogrel (Plavix) by blocking the conversion of clopidogrel to its active form. This combination should be avoided.

Which proton pump inhibitors (PPIs) are approved in the United States?

Available proton pump inhibitors  include:

Medically reviewed by Omudhome Ogbru, PharmD

Reference: FDA Prescribing Information


Medically Reviewed by a Doctor on 4/21/2015


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