- What are proton pump inhibitors (PPIs) and how do they work?
- What are examples of proton pump inhibitors (PPIs) approved in the United States?
- What are the side effects of proton pump inhibitors (PPIs)?
- For what conditions are proton pump inhibitors (PPIs) used?
- Are there differences among proton pump inhibitors (PPIs)?
- What drugs interact with proton pump inhibitors (PPIs)
What are proton pump inhibitors (PPIs) and how do they work?
Proton pump inhibitors (PPIs) reduce the production of acid by blocking the enzyme in the wall of the stomach that produces acid. Acid is necessary for the formation of most ulcers in the esophagus, stomach, and duodenum, and the reduction of acid with PPIs prevents ulcers and allows any ulcers that exist in the esophagus, stomach, and duodenum to heal.
What are examples of proton pump inhibitors (PPIs) approved in the United States?
Available proton pump inhibitors include:
- omeprazole (Prilosec, Prilosec OTC)
- aspirin and omeprazole (Yosprala)
- lansoprazole (Prevacid, Prevacid IV, Prevacid 24-Hour)
- dexlansoprazole (Dexilent, Dexilent Solutab)
- rabeprazole (Aciphex, Aciphex Sprinkle)
- pantoprazole (Protonix)
- esomeprazole (Nexium, Nexium IV, Nexium 24 HR)
- esomeprazole magnesium/naproxen (Vimovo)
- omeprazole/sodium bicarbonate (Zegerid, Zegerid OTC)
Note: The brand name Kapidex was changed to Dexilent to avoid confusion with other drugs.
For what conditions are proton pump inhibitors (PPIs) used?
Proton pump inhibitors are used for the prevention and treatment of acid-related conditions such as:
- Esophageal duodenal and stomach ulcers
- NSAID-associated ulcer
- Gastroesophageal reflux disease (GERD)
- Zollinger-Ellison syndrome.
They also are used in combination with antibiotics for eradicating Helicobacter pylori, a bacterium that together with acid causes ulcers of the stomach and duodenum.
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