- What are protease inhibitors (PIs), and how do they work?
- List of 16 examples of brand and generic names available for protease inhibitors (PIs) in the US
- What are the uses for protease inhibitors (PIs)?
- What are the side effects of HIV protease inhibitors (PIs)?
- What are the side effects of hepatitis C virus (HCV) protease inhibitors?
- What drug interactions occur with protease inhibitors (PIs)?
- Are protease inhibitors (PIs) safe to use during pregnancy or while breastfeeding?
- What forms and preparations of protease inhibitors (PIs) are available?
What are protease inhibitors (PIs), and how do they work?
During infection with HIV or hepatitis C, the HIV or HCV multiply within the body's cells. Viruses are released from the cells and spread throughout the body where they infect other cells. In this manner, HIV and hepatitis C infection is perpetuated among new cells that the body produces continually. During the production of the viruses, new proteins are made. Some of the proteins are structural proteins that form the body of the virus. Other proteins are enzymes that manufacture DNA and other components for the new viruses. Protease is an enzyme that is used in the formation of new structural proteins and enzymes. Protease inhibitors block the activity of protease (cleavage of protein precursors needed for viral structure synthesis) and this results in the formation of defective viruses that are unable to infect the body's cells. As a result, the number of HIV or hepatitis C viruses in the body (the viral load) decreases.
List of 16 examples of brand and generic names available for protease inhibitors (PIs) in the US
HIV protease inhibitors
- Aptivus (tipranavir)
- Reyataz (atazanavir)
- Crixivan, IDV (indinavir)
- Prezista (darunavir)
- Lexiva (fosamprenavir)
- Invirase (saquinavir)
- Kaletra (lopinavir/ritonavir)
- Viracept (nelfinavir)
- Norvir (ritonavir)
Hepatitis C virus (HCV) protease inhibitors
- Victrelis (boceprevir - discontinued)
- Incivek (telaprevir - discontinued)
- Olysio (simeprevir)
- Technivie (ombitasvir/paritaprevir and ritonavir, a combination of these three drugs)
- Viekira Pak (ombitasvir/paritaprevir/ritonavir and dasabuvir, a combination of these four drugs)
Quick GuideHepatitis C (Hep C) Symptoms and Treatment
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