propylthiouracil

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Other important side effects include:

Less common but serious side effects have occurred with PTU therapy. A decrease of white blood cells in the blood (agranulocytosis) may occur. Symptoms and signs of agranulocytosis include infectious lesions of the throat, the gastrointestinal tract, and skin with an overall feeling of illness and fever.

A decrease in blood platelets (thrombocytopenia) also may occur. Since platelets are important for the clotting of blood, thrombocytopenia may lead to excessive bleeding. Severe liver injury and acute liver failure, in some cases fatal, have been associated with PTU. Some adults and pediatric patients required liver transplantation.

GENERIC AVAILABLE: Yes

PRESCRIPTION: Yes

PREPARATIONS: Tablet: 50 mg.

STORAGE: PTU should be stored at room temperature, 15 C - 30 C (59 F - 86 F).

DOSING: The initial adult dose of PTU is 300 mg/day divided into 3 divided doses. PTU is usually administered every eight hours. Patients with large goiters may require initial doses up to 900 mg daily. The usual long-term adult dose after initial treatment is 100-150 mg/day.

DRUG INTERACTIONS: PTU may increase the effect of oral blood thinners, for example warfarin (Coumadin). Therefore, warfarin dose changes and monitoring for the effects of warfarin on blood clotting are necessary.

Hyperthyroidism may cause increased elimination of beta blockers (for example, propranolol [Inderal, Inderal LA, Innopran XL)). Once hyperthyroidism is reversed the excretion of beta-blockers may return to normal and less beta-blocker will be needed to provide the same effect.

Medically Reviewed by a Doctor on 1/13/2015
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