propranolol, Inderal, Inderal LA, Innopran XL (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
Neurotransmitters are chemicals that are produced and released by nerves in order to communicate with each other. The released neurotransmitters attach to receptors on other cells and induce changes within the receptor-containing cells. Norepinephrine is a neurotransmitter that is used by the sympathetic nervous system, a portion of the involuntary nervous system. Nerves of the sympathetic nervous system release norepinephrine that binds to beta receptors on other cells. Propranolol inhibits the sympathetic nervous system by blocking the beta receptors on the nerves of the sympathetic system. Since stimulation of the sympathetic nervous system is responsible for increasing the rate with which the heart beats, by blocking the action of these nerves propranolol reduces the heart rate and is useful in treating abnormally rapid heart rhythms.
Propranolol also reduces the force of contraction of heart muscle and thereby lowers blood pressure. By reducing the heart rate and the force of muscle contraction, propranolol reduces the need for oxygen by heart muscle. Since heart pain (angina pectoris) occurs when oxygen demand of the heart muscle exceeds the supply of oxygen, propranolol, by reducing the demand for oxygen, is helpful in treating heart pain. The FDA approved propranolol in November 1967.
PRESCRIBED FOR: Propranolol is prescribed for patients with high blood pressure (hypertension). It is also used to treat chest pain (angina pectoris) related to coronary artery disease. Propranolol is useful in slowing and regulating certain types of abnormally rapid heart rates (tachycardias). Other uses for propranolol include the prevention of migraine headaches and the treatment of certain types of tremors (familial or hereditary essential tremors). Propranolol is commonly used in persons with thyrotoxicosis (high blood levels of thyroid hormone) to slow down rapid heart rate and tremor.
Medically Reviewed by a Doctor on 1/13/2015
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