PRECAUTIONS: Tell your doctor your medical history, especially of: asthma, anemia, bleeding problems, ulcers, gout, any drug allergies, substance abuse history, emotional or mental problems, liver or heart problems, breathing problems, high blood pressure, severe diarrhea. This combination product contains aspirin. Children and teenagers should not take aspirin if they have chickenpox, influenza or any undiagnosed illness without first consulting a doctor about Reye's syndrome, a rare but serious illness. This medicine may cause stomach bleeding. Daily use of alcohol, especially when combined with this medicine, may increase your risk for stomach bleeding. Check with your doctor or pharmacist for more information. Use caution engaging in activities requiring alertness such as driving or using machinery. Avoid alcoholic beverages. Aspirin is not recommended for use during pregnancy. Consult your doctor before using this drug. This drug is excreted into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before you breast-feed.

DRUG INTERACTIONS: Tell your doctor of all medications you may use (both prescription and nonprescription), especially of: warfarin, cimetidine, acetazolamide, other narcotic pain drugs, corticosteroids, methotrexate, arthritis drugs, gout drugs, drugs used for diabetes. Also report the use of medicines that make you drowsy, such as: sleeping pills, sedatives, anti-anxiety drugs (e.g., diazepam), anti-seizure drugs, muscle relaxants, tranquilizers, psychiatric drugs (e.g., antidepressants), certain antihistamines (e.g., diphenhydramine). Because this medication contains aspirin, check with your doctor or pharmacist before taking other medications containing pain relievers. Pain relievers can be found in many cough-and-cold preparations. This medication contains caffeine. Avoid drinking large amounts of caffeinated beverages while taking this medication as excessive nervousness and irritability can occur. Do not start or stop any medicine without doctor or pharmacist approval.