Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.
Cholestyramine (Questran) reduces the effect of acetaminophen by decreasing
its absorption into the body from the intestine. Therefore, acetaminophen should
be administered 3 to 4 hours after cholestyramine or one hour before
cholestyramine.
Acetaminophen doses greater than 2275 mg per day may increase the blood
thinning effect of warfarin (Coumadin) by an unknown mechanism. Therefore,
prolonged administration or large doses of acetaminophen should be avoided
during warfarin therapy.
PREGNANCY: There are no adequate studies in
pregnant women.
NURSING MOTHERS: Low concentrations of propoxyphene have been measured in the
breast milk of mothers taking propoxyphene. It is not known whether these small
amounts can cause side effects in nursing infants.
SIDE EFFECTS: The most frequent adverse reactions of propoxyphene include
lightheadedness, dizziness, sedation, nausea, and vomiting. Other side effects
include drowsiness, constipation, and spasm of the ureter, which can lead to
difficulty in urinating.
Propoxyphene can depress breathing and, therefore, is used with caution in
elderly, debilitated patients, and in patients with serious lung disease.
Propoxyphene can impair thinking and the physical abilities required for driving
or operating machinery. Propoxyphene may be habit forming. Mental and physical
dependence can occur but are unlikely when it is used short-term.
Arthritis is inflammation of one or more joints. When joints are inflamed they can develop stiffness, warmth, swelling, redness and pain. There are over 100 types of
arthritis including osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, lupus, gout,
and pseudogout.
Drug-induced liver diseases are diseases of the liver that are caused by physician-prescribed medications, OTC medications, vitamins, hormones, herbs, illicit (“recreational”) drugs, and environmental toxins. There are three types of liver toxicity; dose-dependent toxicity, idiosyncratic toxicity, and drug allergy. The types of liver disease drugs cause include: mild elevations of blood levels of liver enzymes, hepatitis, necrosis, cholestasis, steatosis, cirrhosis, mixed disease, fulminant hepatitis, and blood clots.
Tylenol liver damage (acetaminophen) can occur from accidentally ingesting too much acetaminophen, or intentionally. Acetaminophen is a drug contained in over 200 OTC and prescription medications from NyQuil to Vicodin. Avoiding unintentional overdoses include reading medication labels, write down the dosages of medications you are taking, do not drink excessive alcohol while taking acetaminophen. In severe cases, a liver transplant may be necessary.
Pain management and treatment can be simple or complex, according to its cause. There are two basic types of pain, nociceptive pain and neuropathic pain. Some causes of neuropathic pain includes: complex regional pain syndrome, interstitial cystitis, and irritable bowel syndrome. There are a variety of methods to treat chronic pain, which are dependant on the type of pain experienced.
Chronic pain is pain (an unpleasant sense of discomfort) that persists or progresses over a long period of time. In contrast to acute pain that arises suddenly in response to a specific injury and is usually treatable, chronic pain persists over time and is often resistant to medical treatments.