propoxyphene and acetaminophen (cont.)
Cholestyramine (Questran) reduces the effect of acetaminophen by decreasing
its absorption into the body from the intestine. Therefore, acetaminophen should
be administered 3 to 4 hours after cholestyramine or one hour before
cholestyramine.
Acetaminophen doses greater than 2275 mg per day may increase the blood
thinning effect of warfarin (Coumadin) by an unknown mechanism. Therefore,
prolonged administration or large doses of acetaminophen should be avoided
during warfarin therapy.
PREGNANCY: There are no adequate studies in
pregnant women.
NURSING MOTHERS: Low concentrations of propoxyphene have been measured in the
breast milk of mothers taking propoxyphene. It is not known whether these small
amounts can cause side effects in nursing infants.
SIDE EFFECTS: The most frequent adverse reactions of propoxyphene include
lightheadedness, dizziness, sedation, nausea, and vomiting. Other side effects
include drowsiness, constipation, and spasm of the ureter, which can lead to
difficulty in urinating.
Propoxyphene can depress breathing and, therefore, is used with caution in
elderly, debilitated patients, and in patients with serious lung disease.
Propoxyphene can impair thinking and the physical abilities required for driving
or operating machinery. Propoxyphene may be habit forming. Mental and physical
dependence can occur but are unlikely when it is used short-term.
Reference: FDA Prescribing Information
Last Editorial Review: 9/10/2009
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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