propoxyphene, Darvon, Darvon-N, Dolene (cont.)
STORAGE: Capsules and tablets should be stored at room temperature, between 15- 30 C (59-86 F).
PRESCRIBED FOR: Propoxyphene is used for the treatment of mild to moderate pain.
DOSING: The recommended adult dose is 1 capsule (65 mg) or 1 tablet (100 mg) every 4 hours as needed for relief of pain. Doses should not exceed 390 mg (capsule) or 600 mg (tablets) in a 24-hour period.
DRUG INTERACTIONS: Propoxyphene, like other narcotic pain-relievers, increases the effect of drugs that slow brain function, such as alcohol, barbiturates, skeletal muscle relaxants, for example, carisoprodol (Soma) and cyclobenzaprine (Flexeril), and benzodiazepine sedatives, for example, diazepam (Valium) and lorazepam (Ativan). Combined use of muscle relaxants and propoxyphene may lead to increased respiratory depression.
Combining propoxyphene with carbamazepine (Tegretol, Tegretol XR, Equetro, Carbatrol) may have extreme effects on the brain including coma.
Drugs which both stimulate and block opioid receptors, for example pentazocine (Talwin), nalbuphine (Nubain), butorphanol (Stadol), and buprenorphine (Buprenex) may reduce the effect of propoxyphene and may precipitate propoxyphene withdrawal symptoms.
PREGNANCY: There are no adequate studies of propoxyphene in pregnant women.
NURSING MOTHERS: Low concentrations of propoxyphene have been measured in the breast milk of mothers taking propoxyphene. It is not known whether these small amounts can cause side effects in nursing infants.
SIDE EFFECTS: The most frequent adverse reactions of propoxyphene include lightheadedness, dizziness, sedation, nausea, and vomiting. Other side effects include drowsiness, constipation, and spasm of the ureter, which can lead to difficulty in urinating.
Propoxyphene can depress breathing and should be used with caution in elderly, debilitated patients and in patients with serious lung disease. Propoxyphene can impair thinking and the physical abilities required for driving or operating machinery. Propoxyphene may be habit forming. Mental and physical dependence can occur but are unlikely when used for short-term pain relief.
Reference: FDA Prescribing Information
Last Editorial Review: 11/19/2010
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