propafenone, Rythmol, Rythmol SR

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

View the Heart Disease Slideshow

Other important side effects include:

Because of its beta blocking activity, propafenone must be used with caution in patients with weak heart muscle (congestive heart failure), slow heart rate, any form of heart electrical conduction block, low blood pressure, or asthma. The most serious side effect of propafenone is the causing of serious life- threatening irregular heart rhythms (ventricular arrhythmias or pro-arrhythmia) or heart block. It is for this reason that propafenone is started and doses increased while patients are hospitalized in a monitored setting.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Tablets: 150, 225, and 300 mg. Capsules (extended Release): 225, 325, and 425 mg

STORAGE: Tablets should be stored at room temperature 15 C to 30 C (59 F to 86 F) in a tightly closed, light-resistant container.

DOSING: The initial dose is 150 mg every 8 hours of immediate release tablets. The dose may be increased at 3 to 4 day intervals to 225 mg every 8 hours and, if needed, to 300 mg every 8 hours.

When using extended release capsules the initial dose is 225 mg every 12 hours. The dose may be increased at minimum 5 day intervals to 325 every 12 hours and if necessary to 425 mg every 12 hours. The dose should be reduced in patients with liver failure. Propafenone is given with or without food.

DRUG INTERACTIONS: Quinidine (Quinidine Gluconate, Quinidine Sulfate) and fluoxetine (Prozac) inhibit the metabolism of propafenone. Therefore, they should not be combined with propafenone.

Medically Reviewed by a Doctor on 4/2/2015

Quick GuideHeart Disease: Symptoms, Signs, and Causes

Heart Disease: Symptoms, Signs, and Causes
FDA Logo

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

See more info: propafenone on RxList
RxList Logo

Need help identifying pills and medications?

Use the pill identifier tool on RxList.

Subscribe to MedicineNet's Heart Health Newsletter

By clicking Submit, I agree to the MedicineNet's Terms & Conditions & Privacy Policy and understand that I may opt out of MedicineNet's subscriptions at any time.

Health Solutions From Our Sponsors