propafenone, Rythmol, Rythmol SR (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

SIDE EFFECTS: Common side effects of propafenone are:

Other important side effects include:

Because of its beta blocking activity, propafenone must be used with caution in patients with weak heart muscle (congestive heart failure), slow heart rate, any form of heart electrical conduction block, low blood pressure, or asthma. The most serious side effect of propafenone is the causing of serious life- threatening irregular heart rhythms (ventricular arrhythmias or pro-arrhythmia) or heart block. It is for this reason that propafenone is started and doses increased while patients are hospitalized in a monitored setting.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Tablets: 150, 225, and 300 mg. Capsules (extended Release): 225, 325, and 425 mg

STORAGE: Tablets should be stored at room temperature 15 C to 30 C (59 F to 86 F) in a tightly closed, light-resistant container.

DOSING: The initial dose is 150 mg every 8 hours of immediate release tablets. The dose may be increased at 3 to 4 day intervals to 225 mg every 8 hours and, if needed, to 300 mg every 8 hours.

When using extended release capsules the initial dose is 225 mg every 12 hours. The dose may be increased at minimum 5 day intervals to 325 every 12 hours and if necessary to 425 mg every 12 hours. The dose should be reduced in patients with liver failure. Propafenone is given with or without food.

Medically Reviewed by a Doctor on 4/2/2015


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