promethazine and codeine, Phenergan with Codeine

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Syrup: 6.25mg of promethazine and 10mg of codeine per teaspoonful.

STORAGE: Promethazine and codeine should be stored at room temperature, 15C - 25C (59F - 77F) in a tightly closed container protected from light.

PRESCRIBED FOR: Promethazine and codeine is used for the treatment of cough and cold symptoms,

DOSING: The usual adult dose is one teaspoonful every 4 to 6 hours as needed. The maximum dose is two tablespoons daily.

DRUG INTERACTIONS: Excessive sedation may occur when promethazine and codeine is combined with other medications that cause sedation. Such drugs include ethanol, barbiturates, anti-anxiety medications, sedatives, other phenothiazines, and narcotic pain medications.

Promethazine should not be taken with any of the monoamine oxidase (MAO) inhibitor class of antidepressants, for example, isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and procarbazine (Matulane), because of the increased risk of extrapyramidal symptoms (EPS) - uncontrollable movement disorders. Excessive anti-cholinergic effects (described below) can occur when promethazine is used with other antihistamines, for example, diphenhydramine (Benadryl), some phenothiazines, for example, thioridazine,  some tricyclic antidepressants, for example, amitriptyline, clozapine (Clozaril, FazaClo, Versacloz), cyclobenzaprine (Active-Cyclobenzaprine, Amrix, EnovaRX-Cyclobenzaprine HCl, Fexmid)), and disopyramide (Norpace).

Medically Reviewed by a Doctor on 11/26/2014
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