- What is promethazine and codeine, and how does it work (mechanism of action)?
- What brand names are available for promethazine and codeine?
- Is promethazine and codeine available as a generic drug?
- Do I need a prescription for promethazine and codeine?
- What are the side effects of promethazine and codeine?
- What is the dosage for promethazine and codeine?
- Which drugs or supplements interact with promethazine and codeine?
- Is promethazine and codeine safe to take if I'm pregnant or breastfeeding?
- What else should I know about promethazine and codeine?
What is the dosage for promethazine and codeine?
The usual adult dose is one teaspoonful every 4 to 6 hours as needed. The maximum dose is two tablespoons daily.
Which drugs or supplements interact with promethazine and codeine?
Excessive sedation may occur when promethazine and codeine is combined with other medications that cause sedation. Such drugs include ethanol, barbiturates, anti-anxiety medications, sedatives, other phenothiazines, and narcotic pain medications.
Promethazine should not be taken with any of the monoamine oxidase (MAO) inhibitor class of antidepressants, for example, isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and procarbazine (Matulane), because of the increased risk of extrapyramidal symptoms (EPS) - uncontrollable movement disorders. Excessive anti-cholinergic effects (described below) can occur when promethazine is used with other antihistamines, for example, diphenhydramine (Benadryl), some phenothiazines, for example, thioridazine, some tricyclic antidepressants, for example, amitriptyline, clozapine (Clozaril, FazaClo, Versacloz), cyclobenzaprine (Active-Cyclobenzaprine, Amrix, EnovaRX-Cyclobenzaprine HCl, Fexmid)), and disopyramide (Norpace).
There may be an increase in the risk of certain neurologic reactions that affect movement of muscles (EPS, see below) when promethazine is combined with medicines that also cause EPS. Such drugs include antipsychotics, metoclopramide (Metozolv ODT, Reglan), and amoxapine.
Promethazine should not be used with propylthiouracil (PTU) due to the increased risk of low white blood cell counts and increased risk of infections. The reason for this interaction is not known.
Concurrent use of promethazine with the dye used for myelography (X-rays of the spinal cord) can lower the threshold for seizures and thus increase the risk of seizures. Promethazine should be stopped at least 48 hours before myelography and not restarted until at least 24 hours after myelography.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Need help identifying pills and medications?
Use the pill identifier tool on RxList.