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Prolactinoma (cont.)

Do prolactinomas affect oral contraceptives?

In the past, oral contraceptives (birth control pills) were thought to contribute to the development of prolactinomas. However, this notion is no longer held to be true. Patients with prolactinomas who are treated with bromocriptine (Parlodel) or cabergoline (Dostinex) may also take oral contraceptives. Similarly, post-menopausal estrogen replacement is safe in patients with prolactinomas who are treated with medical therapy or surgery.

Is osteoporosis a risk in women with high prolactin levels?

Women whose ovaries produce inadequate estrogen are at an increased risk for osteoporosis. Hyperprolactinemia can cause reduced estrogen production. Although estrogen production may be restored after treatment for hyperprolactinemia, even a year or two without estrogen can decrease the strength of the bones. Women should protect themselves from osteoporosis by regular exercise and increased calcium intake through diet or supplementation, and by avoiding smoking. Women may want to have bone density measurements. They may also want to discuss estrogen replacement therapy with their doctors.

Prolactinoma At A Glance

  • A prolactinoma is a benign tumor of the pituitary gland.

  • Prolactinomas cause secretion of the hormone prolactin, which stimulates the breast to produce milk.

  • The aims of treatment are the reduction of prolactin level to normal, reduction of tumor size, and restoration of normal pituitary function.

  • Most prolactinomas occur sporadically with a low risk of recurrence in the family.

  • However, some prolactinomas are due to a genetic predisposition and carry a high risk of recurrence.

  • The overall success rate in treating prolactinomas is very high.

Reference: National Institutes of Health (NIH).


Last Editorial Review: 4/16/2008




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