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Prolactinoma
(Pituitary Tumor)

Medical Author: Robert Ferry Jr., MD
Medical Editor: Ruchi Mathur, MD, FRCP(C)

What is a prolactinoma (pituitary tumor)?

A prolactinoma is a benign tumor (called an adenoma) of the pituitary gland. A prolactinoma produces an excessive amount of the hormone prolactin. Prolactin is a natural hormone which supports a woman's normal lactation (breastfeeding). Prolactinomas are the most common type of pituitary tumor. Symptoms of prolactinoma are caused by pressure of the tumor on surrounding tissues or by excessive release of prolactin from the tumor into the blood (causing a condition known as hyperprolactinemia).

What is the normal function of prolactin?

Prolactin stimulates the breast tissues to enlarge during pregnancy. After delivery of the baby, the mother's prolactin level falls unless she breastfeeds her infant. Each time the baby nurses from the breasts, prolactin levels rise to maintain milk production.

What is the pituitary gland?

Sometimes called the master gland, the pituitary gland plays a critical role in regulating growth and development, metabolism, and reproduction. This gland produces prolactin and a number of other key hormones including:

  • Growth hormone, which as the name indicates, regulates growth;

  • ACTH (adrenocorticotropin hormone) which stimulates the adrenal glands to produce cortisol, especially during stressful events (surgery, etc.)

  • Thyroid stimulating hormone (TSH), which signals the thyroid gland to produce thyroid hormone; and

  • Luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which regulate ovulation and estrogen and progesterone production in women, and sperm formation and testosterone production in men.


Next: Where is the pituitary gland located? »

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Prolactinoma (Pituitary Tumor)

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