PRECAUTIONS: Before using progesterone, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: unusual vaginal bleeding that has not been diagnosed by your doctor, liver disease, cancer of the breast or female reproductive organs, a miscarriage with some tissue remaining in the womb, blood clots.Before using this medication, tell your doctor or pharmacist your medical history, especially of: seizures, migraines, asthma, heart disease, kidney disease, depression, diabetes.Although unlikely, this medication can cause blood clots. Your risk is increased if you will be having surgery or if you need to stay in a chair or bed for a long period of time (e.g., a long plane flight). Notify your doctor beforehand of any of these events. Special precautions may need to be taken in these circumstances while you are using this drug.If you have diabetes, this medication may make it harder to control your blood sugar levels. Tell your doctor immediately if you develop symptoms of high blood sugar, such as unusual increased thirst and urination. Be sure to check your blood sugar levels regularly.This drug may make you drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages. In general, alcohol is not recommended for pregnant or possibly pregnant women due to the increased risk of harm to the baby.This medication may be used in pregnancy as directed by your doctor. Consult your doctor for more details.This drug passes into breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop or change the dosage of any medicine before checking with them first.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: drugs affecting liver enzymes that remove progesterone from your body (such as rifampin, St. John's wort, azole antifungals including itraconazole, certain anti-seizure medicines including carbamazepine/phenobarbital/phenytoin).If you are directed to use any other vaginal products, separate their application from progesterone gel by at least 6 hours.This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

Report Problems to the Food and Drug Administration You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088. Need help identifying pills and medications? Use the pill identifier tool on RxList.