progesterone intravaginal gel (Crinone, Endometrin)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Pharmacy Author: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

What is progesterone gel-vaginal, and how does it work (mechanism of action)?

  • Progesterone is a female hormone and is the principal progestational hormone. Progestational hormones prepare the uterus (the womb) to receive and sustain the fertilized egg. Progesterone promotes the development of the mammary glands, causes changes in the endometrium, which lines the uterus, relaxes uterine smooth muscles, blocks ovulation within the ovaries, and maintains pregnancy.
  • The FDA approved progesterone intravaginal gel in July 1997.

What brand names are available for progesterone gel-vaginal?

Crinone, Endometrin

Is progesterone gel-vaginal available as a generic drug?


Do I need a prescription for progesterone gel-vaginal?


What are the uses for progesterone gel-vaginal?

  • Intravaginal progesterone gel is used for supplementing or replacing progesterone in infertile women with progesterone deficiency who are receiving treatment utilizing assisted reproductive technology (ART).
  • Progesterone intravaginal gel is also used for the treatment of secondary amenorrhea (absence of menses).
Medically Reviewed by a Doctor on 4/7/2016
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