progesterone

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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GENERIC NAME: Progesterone

BRAND NAME: Prometrium

DRUG CLASS AND MECHANISM: Progesterone is a man-made medication derived from a plant source and is identical to the female hormone, progesterone produced in the ovaries. It promotes the development of the mammary glands, causes changes in the endometrium, which lines the uterus, relaxes uterine smooth muscles, blocks ovulation within the ovaries, and maintains pregnancy. Progesterone was approved in May, 1998.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Capsules: 100 and 200 mg

STORAGE: Progesterone capsules should be stored between 20 C to 25 C (68 F to 77 F) and should be protected from excessive moisture.

PRESCRIBED FOR: Progesterone capsules are used to prevent endometrial enlargement (hyperplasia) in postmenopausal women who have not had their uterus removed (hysterectomy) and who are receiving daily conjugated estrogens. Progesterone capsules also are used for the treatment of secondary amenorrhea (absence of menstrual periods).

DOSING: Prevention of Endometrial Hyperplasia: 200 mg by mouth once daily at bedtime for 12 consecutive days per 28 day cycle. Treatment of Secondary Amenorrhea: 400 mg by mouth once daily at bedtime for 10 days.

DRUG INTERACTIONS: Progesterone should be used with caution with ketoconazole (Nizoral), clarithromycin (Biaxin), and erythromycin (Ery-Tab) because they slow the breakdown of progesterone and increase its levels in the body.

Medically Reviewed by a Doctor on 10/7/2014

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