GENERIC NAME: Progesterone
BRAND NAME: Prometrium
DRUG CLASS AND MECHANISM: Progesterone is a man-made medication derived from a plant source and is identical to the female hormone, progesterone produced in the ovaries. It promotes the development of the mammary glands, causes changes in the endometrium, which lines the uterus, relaxes uterine smooth muscles, blocks ovulation within the ovaries, and maintains pregnancy. Progesterone was approved in May, 1998.
GENERIC AVAILABLE: Yes
PREPARATIONS: Capsules: 100 and 200 mg
STORAGE: Progesterone capsules should be stored between 20 C to 25 C (68 F to 77 F) and should be protected from excessive moisture.
PRESCRIBED FOR: Progesterone capsules are used to prevent endometrial enlargement (hyperplasia) in postmenopausal women who have not had their uterus removed (hysterectomy) and who are receiving daily conjugated estrogens. Progesterone capsules also are used for the treatment of secondary amenorrhea (absence of menstrual periods).
DOSING: Prevention of Endometrial Hyperplasia: 200 mg by mouth once daily at bedtime for 12 consecutive days per 28 day cycle. Treatment of Secondary Amenorrhea: 400 mg by mouth once daily at bedtime for 10 days.
DRUG INTERACTIONS: Progesterone should be used with caution with ketoconazole (Nizoral), clarithromycin (Biaxin), and erythromycin (Ery-Tab) because they slow the breakdown of progesterone and increase its levels in the body.
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