- Acetylcholinesterase inhibitors may decrease the effectives of prochlorperazine. Centrally acting acetylcholinesterase inhibitors may increase the neurotoxic effects of antipsychotic agents.
- Combining prochlorperazine with alcohol, kava kava, CNS depressants, and cannabis may increase the risk of CNS depressant side effects.
- Antacids may decrease the absorption of prochlorperazine.
- Prochlorperazine may cause anticholinergic side effects such as dry mouth, constipation, dry eyes, decreased urinary output, and mental confusion. Combining agents with similar anticholinergic effects increases the risk of experiencing such adverse events.
- Prochlorperazine may increase the blood levels of dofetilide (Tikosyn). Use of both drugs is not recommended.
- Deferoxamine (Desferal) may increase the risk of experiencing side effects of prochlorperazine treatment. Combination use has resulted in the prolonged loss of consciousness.
- Metoclopramide (Reglan) may increase the side effects of antipsychotic agents. Combination use is not recommended.
- Prochlorperazine may increase the CNS depressant effects of orphenadrine (Norflex) or paraldehyde (Paral). Combination use is not recommended.
- Combining prochlorperazine and potassium chloride may result in an increase in the ulcerogenic effect of potassium chloride (Klor-Con). Combination use is generally not recommended.
- Combining prochlorperazine with thalidomide (Thalomid) may increase the risk of experiencing CNS depressant side effects. This combination is generally not recommended.
PREGNANCY: Prochlorperazine has not been adequately evaluated in pregnant women. Due to the lack of conclusive safety data, prochlorperazine should be avoided in pregnancy except in cases of severe nausea and vomiting that requires treatment and potential benefit justifies the potential risk to the fetus.
NURSING MOTHERS: It is not known if prochlorperazine is excreted into human milk. Other phenothiazines are excreted into breast milk. If clearly needed, prochlorperazine should be used cautiously in females who are nursing.
REFERENCE: FDA Prescribing Information.
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