Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.
STORAGE: Prochlorperazine injection solution is recommended to be stored
below 30 C (86 F). All other dosage forms may be stored between 15 C to 30 C (59
F to 86 F).
Treatment of severe nausea and vomiting
The dosage must be adjusted
based on individual patient response.
Patients are generally started on the
lowest recommended dosage.
Oral tablets: The usual recommended dose is one 5 mg or 10 mg tablet orally
3-4 times daily.
Rectal suppository: 25 mg twice daily.
Intramuscular injection: The usual starting dose is 5 to 10 mg injected
deeply into the upper outer quadrant of the buttock. Additional doses may be given
every 3 or 4 hours as necessary. Total daily dose should not exceed 40 mg per
day except in resistant patients.
Intravenous (IV) dosage: The usual recommended dose is 2.5 to10 mg by slow IV
injection or infusion at a rate not to exceed 5 mg per minute. A single dose should not exceed 10 mg.
The total daily dose should not exceed 40 mg
Adult surgery patients with severe nausea or vomiting
The total daily dose
should not exceed 40 mg per day.
Intramuscular injection: The usual recommended dose is 5 to 10 mg, 1 to 2
hours before the administration of anesthesia. A second dose may be given in 30
minutes if necessary. Repeat doses may also be given to control acute symptoms
during and after surgery as needed.
IV dosage: The usual recommended dose is 5 to 10 mg as a slow IV injection or
infusion 15 to 30 minutes before the administration of anesthesia, or to control
acute symptoms during or after surgery.
Adult psychiatric disorders
Individual patient dosage is adjusted based on
response and severity of the condition. Treatment is started with the lowest
Oral dosage: non-psychotic anxiety: The usual recommended dose is 5 mg 3-4
Psychotic disorders including schizophrenia (mild): The usual recommended
dose is 5 to 10 mg 3-4 times daily.
Psychotic disorders including schizophrenia (moderate to severe conditions):
The recommended usual starting dose in hospitalized or adequately supervised
patients is 10 mg 3-4 times daily. Dosage should be increased in small
increments every 2-3 days to minimize the occurrence of side effects. Some
patients may have a satisfactory response to 50 to 75 mg per day. Patient with
severe symptoms may require 100 to 150 mg per day.
Intramuscular dosage: For the immediate control of severe schizophrenia
symptoms in adult patients, patients may be started with an initial dose of 10
to 20 mg administered deeply into the upper outer quadrant of the buttock.
Repeat injections may be given every 2 to 4 hours if necessary.
Pediatric use (dose calculation) is weight-based and the drug should not be
used in children < 2 years old.