procainamide, Pronestyl; Procan-SR; Procanbid (These brands no longer are available in the U.S.) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:
Medical and Pharmacy Editor:

 A severe reduction in white blood cell count occurs relatively rarely with procainamide therapy and is more common with the sustained-release preparations. This side effect has caused death. For this reason, patients on sustained-release procainamide get a complete blood count test (CBC) every 2 weeks for the first 3 months of treatment. A syndrome resembling lupus erythematosus, including fever, chills, joint pain, chest pain, and/or skin rash can occur with procainamide. The lupus-like syndrome is reversible after stopping the drug. Rarely, procainamide can cause confusion, hallucinations, and depression.

Reference: FDA Prescribing Information

Medically Reviewed by a Doctor on 8/26/2014

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