Table of Contents
- What are probiotics?
- What are probiotics? (Continued)
- What are prebiotics and synbiotics?
- What are microbes and their role in our health?
- What are the health benefits of probiotics?
- What are the health benefits of probiotics? (Continued)
- What are the different types of probiotics?
- What are the different types of probiotics? (Part 2)
- What are the different types of probiotics? (Part 3)
- What foods contain probiotics?
- What foods contain probiotics? (Part 2)
- What foods contain probiotics? (Part 3)
- What are the side effects and risks of probiotics?
- How should people take probiotics?
Quick GuideDigestive Health: Top Foods for Probiotics
What are prebiotics and synbiotics?
The prebiotic comes before and helps the probiotic, and then the two can combine to have a synergistic effect, known as synbiotics. A prebiotic is actually a nondigestible carbohydrate that acts as food for the probiotics and bacteria in your gut. The definition of the effect of prebiotics is the selective stimulation of growth and/or activity(ies) of one or a limited number of microbial genus(era)/species in the gut microbiota that confer(s) health benefits to the host. The health benefits have been suggested to include acting as a remedy for gastrointestinal (GI) complications such as enteritis, constipation, and irritable bowel disease; prevention and treatment of various cancers; decreasing allergic inflammation; treatment of nonalcoholic fatty liver disease (NAFLD), and fighting immune deficiency diseases. There has also been research showing that the dietary intake of particular food products with a prebiotic effect has been shown, especially in adolescents, but also tentatively in postmenopausal women, to increase calcium absorption as well as bone calcium accretion and bone mineral density. The benefits for obesity and type 2 diabetes are growing as recent data, both from experimental models and from human studies, have shown particular food products with prebiotics have influences on energy homeostasis, satiety regulation, and body weight gain.
Most of the prebiotics identified are oligosaccharides. They are resistant to the human digestive enzymes that work on all other carbohydrates. This means that they pass through the upper GI system without being digested. They then get fermented in the lower colon and produce short-chain fatty acids that will then nourish the beneficial microbiota that live there. Oligosaccharides can be synthesized or obtained from natural sources. These sources include asparagus, artichoke, bamboo shoots, banana, barley, chicory, leeks, garlic, honey, lentils, milk, mustards, onion, rye, soybean, sugar beet, sugarcane juice, tomato, wheat, and yacón. The health benefits from these oligosaccharides is a topic of ongoing research. Continue Reading
Alm, L. "Therapeutic Properties of Fermented Milk." Elseveir Science (1991): 45-64.
Baquerizo Nole, K.L. "Probiotics and Prebiotics in Dermatology." J Am Acad Dermatol. 71.4 Oct. 2014: 814-821.
Beighton, D. "Oral Bifidobacteria: Caries-associated Bacteria in Older Adults." J Dent Res 89.9 Sept. 2010: 970-974.
Bellaguarda, E. "IBD and the gut microbiota--from bench to personalized medicine." Curr Gastroenterol Rep. 17.4 Apr. 2015: 15.
Brown, K. "Diet-induced dysbiosis of the intestinal microbiota and the effects on immunity and disease." Nutrients 4.8 (2012): 1095-1119.
Delorme, C. "Safety assessment of dairy microorganisms: Streptococcus thermophilus." Int J Food Microbiol 126.3 Sept. 2008: 274-277.
Dimidi, E. "The effect of probiotics on functional constipation in adults: a systematic review and meta-analysis of randomized controlled trials." Am J Clin Nutr. 100.4 Oct. 2014: 1075-1084.
Dupont, A.W. Nat Rev Gastroenterol Hepatol Aug. 2011; Epub ahead of print
Fijan, S. "Microorganisms with claimed probiotic properties: an overview of recent literature." Int J Environ Res Public Health. 11.5 May 5, 2014: 4745-4767.
Fisberg, M., and R. Machado. "History of yogurt and current patterns of consumption." Nutr Rev. 73 Suppl 1:4-7 Aug. 2015.
The Food and Agriculture Organization of the United Nations
Goyal, R. "The Enteric Nervous System." NEJM 334 Apr. 1996: 1106-1115.
Guarner, F. "Gut Flora in Health and Disease." Lancet 361.9356 Feb. 2003: 512-519.
Hadhazy, Adam. "Think Twice: How the Gut's 'Second Brain' Influences Mood and Well-Being." Scientific American Feb. 12, 2010. <http://www.scientificamerican.com/article.cfm?id=gut-second-brain>.
"Health Benefits of Taking Probiotics." The Harvard Medical School Family Health Guide Sept. 2005. <http://www.health.harvard.edu/fhg/updates/update0905c.shtml>.
Hickson, M. "Probiotics in the prevention of antibiotic-associated diarrhea and Clostridium difficile infection." Therap Adv Gastroenterol 4.3 May 2011: 185-197.
Hill, C. "Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic." Nat Rev Gastroenterol Hepatol 11.8 Aug. 2014: 506-514.
Ishibashi, N. "Probiotics and Safety." Am J Clin Nutr 73.2 Suppl Feb. 2001: 465S-470S.
Iyer, C., et al. "Probiotic Lactobacillus reuteri promotes TNF-induced apoptosis in human myeloid leukemia-derived cells by modulation of NF-kB and MAPK signaling." Cell Microbiol 10.7 July 2008: 1442-1452.
Kabeerdoss, J. Nut J 10.138 Dec. 2011.
Kabir, M.A. "Role of Saccharomyces boulardii in diarrhea predominant irritable bowel syndrome." Mymensingh Med J 20.3 July 2011: 397-401.
Kathari, D. "Therapeutic spectrum of nondigestible oligosaccharides: overview of current state and prospect." J Food Sci. 79.8 Aug. 2014: R1491-8.
Kaur, R. Int J Paediatr Dent 10 Feb. 2012: 1363-1365.
Khalesi, S. "Effect of probiotics on blood pressure: a systematic review and meta-analysis of randomized, controlled trials." Hypertension 64.4 Oct. 2014: 897-903.
Kochan, P. Clin Microbiol Infect 10 June 2011: Epub ahead of print
Kong, X.Y. "Probiotics' preventive effect on pediatric food allergy: a meta-analysis of randomized controlled trials." Chin Med Sci J 29.3 Sept. 2014: 144-147.
"Lactobacillus." MedlinePlus. Dec. 9, 2011. <http://www.nlm.nih.gov/medlineplus/druginfo/natural/790.html>.
López-Cepero, A.A. "Association of the Intestinal Microbiota and Obesity." P R Health Sci J 34.2 June 2015: 60-4.
Makowiak, P. "Recycling metchnikoff: probiotics, the intestinal microbiome and the quest for long life." Front Public Health 1 (2013): 52.
Margolis, K. Curr Opinions Gastroenterology 25.6 Nov. 2009: 503-511.
Meini, S. "Breakthrough Lactobacillus rhamnosus GG bacteremia associated with probiotic use in an adult patient with severe active ulcerative colitis: case report and review of the literature." Infection May 30, 2015. [Epub ahead of print]
Murooka, Y. "Traditional healthful fermented products of Japan." J Ind Microbiol Biotechnol 35.8 Aug. 2008: 791-8.
National Institute of Health
Ostadrahimi, A. "Effect of probiotic fermented milk (kefir) on glycemic control and lipid profile in type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial." Iran J Public Health 44.2 Feb. 2015: 228-37.
Park, K.Y. "Health benefits of kimchi (Korean fermented vegetables) as a probiotic food." J Med Food 17.1 Jan. 2014: 6-20.
Picard, C. Aliment Pharmacol Ther 22.6 Sept. 2005: 495-512.
"Probiotic/Prebiotic Science." International Scientific Association for Probiotics an Prebiotics." <http://www.isapp.net/Probiotics-and-Prebiotics/The-Science>.
Quigley, E. "Small Intestinal Bacterial Overgrowth: Roles of Antibiotics, Prebiotics, and Probiotics." Gastroenterology 130.2 Suppl 1 Feb. 2006: S78-90.
Roberfroid, M. "Prebiotic effects: metabolic and health benefits." Br J Nutr 104 Suppl 2 Aug. 2010: S1-63.
Saez-Lara, M.J. "The role of probiotic lactic acid bacteria and bifidobacteria in the prevention and treatment of inflammatory bowel disease and other related diseases: a systematic review of randomized human clinical trials." Biomed Res Int (2015): 505875.
"Safety of Probiotics Used to Reduce Risk and Prevent or Treat Disease." Agency for Healthcare Research and Quality. Apr. 2011 <http://www.ahrq.gov/clinic/tp/probiotictp.htm#Report>.
Swain, M.R. "Fermented fruits and vegetables of Asia: a potential source of probiotics." Biotechnol Res Int (2014): 250424.
Theodoru, V. "Effect of commensals and probiotics on visceral sensitivity and pain in irritable bowel syndrome." Gut Microbes 5.3 May-June 2014: 430-436.
United States. Centers for Disease Control and Prevention.
United States. National Center for Complementary and Alternative Medicine. "Oral Probiotics: An Introduction." Nov. 2011. <http://nccam.nih.gov/health/probiotics/introduction.htm>.
United States. National Institutes of Health. "NIH Human Microbiome Project Defines Normal Bacterial Makeup of the Body." June 13, 2012. <http://www.nih.gov/news/health/jun2012/nhgri-13.htm>.
United States. Department of Health & Human Services
Whorwell, P.J. Am J Gastroenterol 10.7 July 2006: 1581-1590.
The World Health Organization
Wu, G.D. "Linking long-term dietary patterns with gut microbial enterotypes." Science 334.6052 Oct. 7, 2011: 105-108.
Zhang, W., et al. "Probiotic Lactobacillus acidophilus enhances the immunogenicity of an oral rotavirus vaccine in gnotobiotic pigs." Vaccine 26.29-30 July 2008: 3655-3661.
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