probenecid, (Benemid - brand no longer available) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

DOSING: The usual adult dose for hyperuricemia is 500 mg twice daily and the maximum dose is 2 grams daily. When combined with penicillin type antibiotics to treat infections, the usual dose is 500 mg 4 times daily. Patients should drink plenty of water in order to prevent formation of kidney stones and take probenecid with food or antacid to reduce stomach upset.

DRUG INTERACTIONS: Probenecid blocks excretion of some drugs by the kidney and, therefore, may increase blood levels and side effects of methotrexate (Rheumatrex, Trexall) and nonsteroidal antiinflammatory drugs (NSAIDs), for example, ibuprofen (Advil), naproxen (Aleve), indomethacin (Indocin), ketorolac (Toradol) and others. Aspirin may reduce the action of probenecid through unknown mechanisms.

PREGNANCY: Probenecid has not been adequately studied in pregnant women.

NURSING MOTHERS: Probenecid has not been adequately studied in nursing mothers.

SIDE EFFECTS: Common side effects of probenecid include headache, dizziness, nausea, vomiting, skin rash, sore gums, and fever. Probenecid may cause a flare of gout and kidney stones, and it is not started during an acute attack of gout. Serious but rare side effects include reduced red blood cell counts (anemia), liver damage and severe allergic reactions.

Reference: FDA Prescribing Information

Last Editorial Review: 2/27/2009

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