probenecid, (Benemid - brand no longer available) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

PREPARATIONS: Tablets: 0.5 g

DRUG INTERACTIONS: Probenecid blocks excretion of some drugs by the kidney and, therefore, may increase blood levels and side effects of methotrexate (Rheumatrex, Trexall) and nonsteroidal antiinflammatory drugs (NSAIDs), for example, ibuprofen (Advil), naproxen (Aleve), indomethacin (Indocin), ketorolac (Toradol) and others. Aspirin may reduce the action of probenecid through unknown mechanisms.

PREGNANCY AND BREASTFEEDING SAFETY: Probenecid has not been adequately studied in pregnant women.

Probenecid has not been adequately studied in nursing mothers.

STORAGE: Probenecid should be stored at room temperature, 15 C - 30 C (59 F - 86 F).

DOSING: The usual adult dose for hyperuricemia is 500 mg twice daily and the maximum dose is 2 grams daily. When combined with penicillin type antibiotics to treat infections, the usual dose is 500 mg 4 times daily. Patients should drink plenty of water in order to prevent formation of kidney stones and take probenecid with food or antacid to reduce stomach upset.

Medically Reviewed by a Doctor on 1/5/2016


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