probenecid, (Benemid - brand no longer available)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

What is probenecid, and how does it work (mechanism of action)?

Probenecid is an oral drug used for reducing blood uric acid levels in patients with hyperuricemia (high uric acid) and/or. High uric acid can cause attacks of gout and kidney stones. Probenecid prevents attacks of gout by reducing uric acid levels in the blood. It does this by preventing the reabsorption of uric acid by the kidney and increasing its excretion from the body in the urine. Probenecid also blocks excretion by the kidney of penicillin and related antibiotics and is used for increasing the levels of the antibiotics in the blood and increasing their effectiveness when treating infections.

Is probenecid available as a generic drug?

GENERIC AVAILABLE: Yes

Do I need a prescription for probenecid?

Yes

What are the uses for probenecid?

Probenecid is used for the treatment of hyperuricemia associated with gout. It also is used for increasing blood levels of penicillin-type antibiotics (for example, ampicillin and amoxicillin) when treating gonorrhea.

What are the side effects of probenecid?

Common side effects of probenecid include:

Probenecid may cause a flare of gout and kidney stones, and it is not started during an acute attack of gout. Serious but rare side effects include reduced red blood cell counts (anemia), liver damage and severe allergic reactions.

Medically Reviewed by a Doctor on 1/5/2016

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