primidone, Mysoline (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
PREPARATIONS: Tablets: 50 and 250 mg
DRUG INTERACTIONS: Primidone may decrease blood levels and the effect of several drugs by increasing the activity of liver enzymes that breakdown these drugs. Examples of drugs affected by Primidone include naloxegol (Movantik), roflumilast (Daliresp), lurasidone (Latuda), and many others.
PREGNANCY AND BREASTFEEDING SAFETY: Primidone has not been adequately evaluated in pregnant women. Some other seizure medications have been associated with birth defects. Primidone is excreted in human milk and may cause adverse effects in the infant.
STORAGE: Primidone should be stored at room temperature, 20 C - 25 C (68 F - 77 F).
DRUG CLASS AND MECHANISM: Primidone is an oral anticonvulsant (anti-seizure) medication used for treating several types of seizures. Its exact mechanism of action is not known. Primidone is converted into phenobarbital and phenylethylmalonamide (PEMA) in the body. Primidone, phenobarbital, and PEMA all have anticonvulsant activity. In addition to its anticonvulsant activity, PEMA increases the anticonvulsant activity of phenobarbital. The FDA approved primidone in March, 1954.
Reference: FDA Prescribing Information
Medically Reviewed by a Doctor on 1/21/2016
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