Primary Biliary Cirrhosis (PBC) (cont.)

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How is the diagnosis of primary biliary cirrhosis made?

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The diagnosis of primary biliary cirrhosis is considered when the doctor suspects that there might be liver inflammation based upon the history and physical examination. Initially there may be few symptoms like itching or fatigue to help guide further testing

The diagnosis may be made incidentally should abnormal liver functions be found on routine blood tests drawn for another reason. Liver function tests include AST (aspartate aminotransferase), ALT (alanine aminotransferase), GGT (gamma-glutamyl transpeptidase), alkaline phosphatase and bilirubin. Blood levels tend to become elevated in liver disease and they may rise in specific patterns depending upon the underlying cause of inflammation.

Once the diagnosis is suspected, a blood test to check for antimitochondrial antibody (AMA) is usually done. This is positive in 90% to 95% of patients with PBC.

Other blood tests may be considered including a complete blood count (CBC) and cholesterol levels.

Imaging of the abdomen by ultrasound, CT scan or MRI is often considered to look for structural changes in the liver and to search for tumors.

A liver biopsy, where a thin needle is inserted through the skin to take a piece of liver tissue, may help confirm the diagnosis. This tissue is examined under a microscope by a pathologist to look for changes consistent with PBC. It is also useful in help stage the disease, deciding its severity at the time of diagnosis.

Medically Reviewed by a Doctor on 4/23/2014

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