Premenstrual Dysphoric Disorder (PMDD)
Medical Author: Melissa Conrad Stöppler, MD
Medical Editor: William C. Shiel, Jr., MD, FACP, FACR
PMS vs. PMDD - What's the Difference?
Medical Author: Carolyn Janet Crandall, M.D., FACP
Medical Editors: Melissa Conrad Stöppler, MD
 Ms. B.T. is 38 years old. Her co-workers always
seem to know when she has her period. During this time, she becomes extremely
irritable. She feels guilty because she gets very angry at her children for no
logical reason or for apparently trivial reasons. In fact, one of her coworkers,
with whom she is quite friendly, suggested she come in before her supervisor
noticed problems on the job. She heard that there is a severe version of PMS
that requires special treatment. Ms. B.T. wants to know if this is her problem.
Premenstrual syndrome (PMS) has been the term
used for mood, and sometimes physical, symptoms that occur cyclically
(predictably in relation to menses) in the second half of the menstrual cycle and interfere with a woman's
quality of life. Some women experience even more severe symptoms. These women may have
a conditions known as premenstrual dysphoric disorder (PMDD).
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What is premenstrual dysphoric disorder (PMDD)?
Premenstrual dysphoric disorder (PMDD) can be considered to be a severe form
of premenstrual syndrome (PMS). Both PMS and PMDD are characterized by
unpleasant physical and psychological symptoms that occur in the second half of
a woman's menstrual cycle,
most commonly in the days preceding the menstrual period. Fatigue, mood changes, irritability, and abdominal bloating are among the most common symptoms of PMS and PMDD, but numerous other symptoms have been reported. Whereas the symptoms of PMS may be troubling and unpleasant, PMDD may cause severe, debilitating symptoms that interfere with a woman's ability to function.
PMS is much more common than PMDD. PMS may affect to 30% of women with regular menstrual cycles, while only 3% to 8% of these women have true PMDD.
PMDD has been previously medically referred to as late luteal phase dysphoric disorder.
What causes PMDD?
Although the precise cause of PMS and PMDD is unknown, it is believed that
these conditions result from the interaction of hormones produced by the ovaries
at different stages in the menstrual cycle (such as estrogen and progesterone)
with the neurotransmitters (chemicals that serve as messengers) in the brain.
While the ovarian hormone levels are normal in women with PMDD, it is likely
that the brain's response to these normally-fluctuating hormone levels is
abnormal.
Most evidence suggests that PMS and PMDD do not result from any specific
personality traits or personality types. While stress clearly is associated with
PMS and PMDD, it is not considered to be a cause of PMDD. Rather, the associated
stress is more likely to be a result of the symptoms of PMS or PMDD. Vitamin or
other nutritional deficiencies have not been shown to cause PMS or PMDD.
Next: What are the symptoms of PMDD? »
- citalopram, Celexa - Information about citalopram (Celexa) an antidepressant drug prescribed for depression, anxiety, OCD, panic disorder, PTSD, and premenstrual dysphoric syndrome.
- Depression - Read about depression causes, symptoms, diagnosis, treatment and types, including manic depression (bipolar disorder), postpartum depression and clinical depression.
- sertraline, Zoloft - Information on the medication sertraline (Zoloft) a drug used to treat depression, obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, social anxiety disorder, and postmenstrual dysphoric disorder. Article includes descriptions, uses, drug interactions, and side effects.
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Premenstrual Dysphoric Disorder (PMDD)
Depression »
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Depressive disorders have been with mankind since the beginning of recorded history. In the Bible, King David, as well as Job, suffered from this affliction. Hippocrates referred to depression as melancholia, which literally means black bile. Black bile, along with blood, phlegm, and yellow bile were the four humors (fluids) that described the basic medical physiology theory of that time. Depression, also referred to as clinical depression, has been portrayed in literature and the arts for hundreds of years, but what do we mean today when we refer to a depressive disorder? In the 19th century, depression was seen as an inherited weakness of temperament. In the first half of the 20th century, Freud linked the development of depression to guilt and conflict. John Cheever, the author and a modern sufferer of depressive disorder, wrote of conflict and experiences with his parents as influencing his development of depression.
In the 19...
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