Premenstrual Dysphoric Disorder (PMDD)

Medical Author:
Medical Editor:

What is premenstrual dysphoric disorder (PMDD)?

Comment on this

Premenstrual dysphoric disorder (PMDD) can be considered to be a severe form of premenstrual syndrome (PMS). Both PMS and PMDD are characterized by unpleasant physical and psychological symptoms that occur in the second half of a woman's menstrual cycle, most commonly in the days preceding the menstrual period. Fatigue, mood changes, irritability, and abdominal bloating are among the most common symptoms of PMS and PMDD, but numerous other symptoms have been reported. Whereas the symptoms of PMS may be troubling and unpleasant, PMDD may cause severe, debilitating symptoms that interfere with a woman's ability to function.

PMS is much more common than PMDD. PMS may affect to 30% of women with regular menstrual cycles, while only 3% to 8% of these women have true PMDD.

PMDD has been previously medically referred to as late luteal phase dysphoric disorder.

What causes PMDD?

Comment on this

Although the precise cause of PMS and PMDD is unknown, it is believed that these conditions result from the interaction of hormones produced by the ovaries at different stages in the menstrual cycle (such as estrogen and progesterone) with the neurotransmitters (chemicals that serve as messengers) in the brain. While the ovarian hormone levels are normal in women with PMDD, it is likely that the brain's response to these normally-fluctuating hormone levels is abnormal.

Most evidence suggests that PMS and PMDD do not result from any specific personality traits or personality types. While stress clearly is associated with PMS and PMDD, it is not considered to be a cause of PMDD. Rather, the associated stress is more likely to be a result of the symptoms of PMS or PMDD. Vitamin or other nutritional deficiencies have not been shown to cause PMS or PMDD.



Patient Comments

Viewers share their comments

Premenstrual Dysphoric Disorder (PMDD) - Experience Question: Please describe your experience with PMDD.
Premenstrual Dysphoric Disorder (PMDD) - Symptoms Question: What were the symptoms of your PMDD?
Premenstrual Dysphoric Disorder (PMDD) - Treatment Question: What was the treatment for your PMDD?
Premenstrual Dysphoric Disorder (PMDD) - Causes Question: What caused your PMDD?
Is PMS different from PMS?

PMS vs. PMDD - What's the Difference?

Medical Author: Carolyn Janet Crandall, M.D., FACP
Medical Editors: Melissa Conrad Stöppler, MD

Ms. B.T. is 38 years old. Her co-workers always seem to know when she has her period. During this time, she becomes extremely irritable. She feels guilty because she gets very angry at her children for no logical reason or for apparently trivial reasons. In fact, one of her coworkers, with whom she is quite friendly, suggested she come in before her supervisor noticed problems on the job. She heard that there is a severe version of PMS that requires special treatment. Ms. B.T. wants to know if this is her problem.

Premenstrual syndrome(PMS) has been the term used for mood, and sometimes physical, symptoms that occur cyclically (predictably in relation to menses) in the second half of the menstrual cycle and interfere with a woman's quality of life. Some women experience even more severe symptoms. These women may have a conditions known as premenstrual dysphoric disorder (PMDD).

Get the latest health and medical information delivered direct to your inbox FREE!