Premature Ovarian Failure (POF) (cont.)
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What causes primary ovarian insufficiency?
In about 90% of cases, the exact cause of POI is a mystery.4,6,11
Research shows that POI is related to problems with the follicles (pronounced FOL-i-kulz)—the small sacs in the ovaries in which eggs grow and mature.6
Follicles start out as microscopic seeds called primordial (pronounced prahy-MAWR-dee-uhl) follicles. These seeds are not yet follicles, but they can grow into them. Normally, a woman is born with approximately 2 million primordial follicles,12 typically enough to last until she goes through natural menopause, usually around age 50.4
For a woman with POI, there are problems with the follicles:1
Although the exact cause is unknown in a majority of cases, some causes of follicle depletion and dysfunction have been identified:
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