- Tablets 1. 2.5, 5, 10, 20, 25, and 50 mg
- Tablets (extended release) 1, 2, 5 mg
- Oral solution or syrup of 5 mg/5ml
PREDNISONE DRUG INTERACTIONS:
Prednisone interacts with many drugs. Here are a few examples of prednisone interactions with other drugs.
- The risk of hypokalemia (low potassium) increases when corticosteroids are combined with drugs that reduce potassium levels (for example, amphotericin B, diuretics), leading to serious side effects such as heart enlargement and congestive heart failure.
- Corticosteroids may increase or decrease the response to warfarin (Jantoven, Coumadin), a blood thinner. Therefore, warfarin therapy should be monitored closely.
- The response to diabetic drugs may be reduced because prednisone increases blood glucose.
- Prednisone may increase the risk of tendon rupture in patients treated with fluoroquinolone type antibiotics. Examples of fluoroquinolones include ciprofloxacin (Cipro) and levofloxacin (Levaquin). The elderly are especially at risk, and tendon rupture may occur during or after treatment with fluoroquinolones.
- Combining aspirin, ibuprofen (Motrin) or other nonsteroidal anti-inflammatory agents (NSAIDS) with corticosteroids increases the risk of stomach related side effects.
- Barbiturates, carbamazepine, rifampin and other drugs that increase the activity of liver enzymes that breakdown prednisone reduce blood levels of prednisone. Conversely, ketoconazole, itraconazole (Sporanox), ritonavir (Norvir), indinavir (Crixivan), macrolide antibiotics such as erythromycin, and other drugs that reduce the activity of liver enzymes that breakdown prednisone increase blood levels of prednisone.
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