prednisolone (Flo-Pred, Pediapred, Orapred, Orapred ODT) (cont.)

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PREGNANCY: Prednisolone can cause fetal harm (cleft lip or palate) when used by pregnant women.

NURSING MOTHERS: Prednisolone is secreted in human milk at 5% to 25% of the nursing mother's blood level. High doses of prednisolone may cause growth problems in the infant.

SIDE EFFECTS: Prednisolone side effects depend on the dose, the duration and the frequency of administration. Short courses of prednisolone - days to a week or two - are usually well tolerated with few and mild side effects. Long-term, high doses of prednisolone will usually produce predictable and potentially serious side effects. Whenever possible, the lowest effective doses of prednisolone should be used for the shortest length of time to minimize side effects. Alternate day dosing can also help reduce side effects.

Side effects of prednisolone and other corticosteroids range from mild annoyances to serious irreversible damage. Side effects include fluid retention, weight gain, high blood pressure, potassium loss, headache, muscle weakness, puffiness of and hair growth on the face, thinning and easy bruising of the skin, glaucoma, cataracts, peptic ulceration, worsening of diabetes, irregular menses, growth retardation in children, convulsions, and psychic disturbances. Psychic disturbances can include depression, euphoria, insomnia, mood swings, personality changes, and even psychotic behavior.

Medically Reviewed by a Doctor on 8/7/2014


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