prazosin (Minipress)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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GENERIC NAME: prazosin hydrochloride

BRAND NAME: Minipress

DRUG CLASS AND MECHANISM: Prazosin (Minipress) is an oral medicine used to treat high blood pressure. Prazosin is a competitive alpha-1 adrenergic receptor blocker. By blocking alpha-1 receptors on muscle cesll that surround blood vessels, prazosin causes vasodilation (widening) of the blood vessels, and consequently decreases the resistance of blood flow. The overall benefit of its use is a decrease in blood pressure.

Prazosin seems to have a bigger impact on reducing the diastolic blood pressure than systolic blood pressure. Diastolic blood pressure is indicated by the second set of numbers in the blood pressure reading and corresponds to the minimum pressure in the arteries when the heart muscles are relaxed and the chambers of the heart are filling with blood.

Prazosin was approved by the FDA in 1976.

PRESCRIBED FOR: Prazosin is used to treat high blood pressure. It can be used alone or in combination with other medications to lower blood pressure.

Prazosin also may be prescribed to certain patients with:

SIDE EFFECTS: The most common side effects associated with prazosin treatment include:

Medically Reviewed by a Doctor on 6/1/2015

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