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- What is prazosin-oral, and how does it work (mechanism of action)?
- What brand names are available for prazosin-oral?
- Is prazosin-oral available as a generic drug?
- Do I need a prescription for prazosin-oral?
- What are the side effects of prazosin-oral?
- What is the dosage for prazosin-oral?
- Which drugs or supplements interact with prazosin-oral?
- Is prazosin-oral safe to take if I'm pregnant or breastfeeding?
- What else should I know about prazosin-oral?
What is prazosin-oral, and how does it work (mechanism of action)?
Prazosin (Minipress) is an oral medicine used to treat high blood pressure. Prazosin is a competitive alpha-1 adrenergic receptor blocker. By blocking alpha-1 receptors on muscle cesll that surround blood vessels, prazosin causes vasodilation (widening) of the blood vessels, and consequently decreases the resistance of blood flow. The overall benefit of its use is a decrease in blood pressure.
Prazosin seems to have a bigger impact on reducing the diastolic blood pressure than systolic blood pressure. Diastolic blood pressure is indicated by the second set of numbers in the blood pressure reading and corresponds to the minimum pressure in the arteries when the heart muscles are relaxed and the chambers of the heart are filling with blood.
Prazosin was approved by the FDA in 1976.
What brand names are available for prazosin-oral?
Is prazosin-oral available as a generic drug?
GENERIC AVAILABLE: Yes
Do I need a prescription for prazosin-oral?
What are the side effects of prazosin-oral?
The most common side effects associated with prazosin treatment include:
Patients can lower their chance of feeling dizzy or passing out by:
- rising slowing from a sitting or lying position,
- climbing stairs slowly,
- avoiding alcohol, and
- drinking lots of water especially in hot weather or while being active.
Additionally, patients should have their blood pressure checked regularly.
Less common side effects include:
- water retention (edema),
- orthostatic hypotension,
- shortness of breath,
- fainting (syncope),
- motion sickness,
- urinary frequency,
- blurred vision,
- reddened sclera,
- dry mouth, and nasal
Rare side effects include:
- stomach pain,
- liver problems,
- tachycardia (fast heartbeat),
- paresthesia (numbness, tingling, burning, prickling),
- hair loss,
- urinary incontinence (loss of bladder control),
- sexual dysfunction,
- prolonged erection,
- ringing in the ears,
- fever, and
- joint pain.
Other side effects reported in post-marketing trials include:
- allergic reaction,
- chest pain,
- low blood pressure,
- gynecomastia (enlargement of mens' breasts, bradycardia [slow heartbeat]),
- difficulty sleeping,
- vasculitis, and
- eye pain.
Quick GuideHow to Lower Blood Pressure: Exercise Tips
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