pravastatin, Pravigard PAC (discontinued) (cont.)

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PREPARATIONS: Tablets: 10, 20, 40, and 80 mg

STORAGE: Pravastatin should be stored at room temperature, between 15-30 C (58-86 F).

DOSING: The dose range of pravastatin is 10-80 mg daily. The usual starting dose in adults is 40 mg once daily. The maximum dose is 80 mg per day. The starting dose for patients with major liver or kidney dysfunction is 10 mg daily.

The dose for children (8-13 years old) is 20 mg daily, and the dose for adolescents (14-18 years old) is 40 mg daily.

DRUG INTERACTIONS: Bile acid sequestrants such as cholestyramine (Questran) may reduce the absorption of pravastatin from the intestine and thereby reduce its effects. Therefore, pravastatin should be taken one hour before or four hours after bile acid sequestrants. The use of pravastatin with nicotinic acid, gemfibrozil (Lopid) or other drugs that cause liver or muscle problems may increase the risk of muscle problems.

PREGNANCY: Statins should not be used by pregnant women because they impair fetal development.

NURSING MOTHERS: A small amount of pravastatin is excreted in breast milk. Because of the risk of toxicity to the infant, nursing mothers should not nurse while taking pravastatin.

Medically reviewed by Eni Williams, PharmD

REFERENCE: FDA Prescribing Information for Pravachol

Medically Reviewed by a Doctor on 10/9/2015

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