pravastatin, Pravigard PAC (discontinued) (cont.)

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Scientists have discovered that inflammation of the coronary arteries also may contribute to arteriosclerotic vascular disease. Inflammation is associated with elevated levels of a protein called C-reactive protein in the blood. This C-reactive protein can be measured by a test, referred to as the "highly-sensitive" C-reactive protein test (Hs-CRP). Elevated levels of Hs-CRP predict the occurrence of heart attacks, strokes, and death. In fact, Hs-CRP is a better predictor of heart attacks, strokes, and death than cholesterol levels. Statins reduce the levels of Hs-CRP, and it has been suggested that statins may reduce arteriosclerotic vascular disease by reducing inflammation in addition to lowering levels of cholesterol. Pravastatin was approved by the FDA in October 1991.



PREPARATIONS: Tablets: 10, 20, 40, and 80 mg

STORAGE: Pravastatin should be stored at room temperature, between 15-30 C (58-86 F).

PRESCRIBED FOR: Pravastatin is used for treating individuals who have or are at risk for arteriosclerotic vascular disease and its consequences, heart attacks, and strokes. Pravastatin provides the following benefits:

  • Reduces total cholesterol Reduces LDL cholesterol
  • Reduces triglycerides Increases HDL cholesterol
  • Reduces the risk of heart attacks Reduces the risk of death
  • Reduces the need to undergo procedures to open up the arteries of the heart
  • Reduces the risk of strokes and transient ischemic attacks (TIAs or mini-strokes)

DOSING: The dose range of pravastatin is 10-80 mg daily. The usual starting dose in adults is 40 mg once daily. The maximum dose is 80 mg per day. The starting dose for patients with major liver or kidney dysfunction is 10 mg daily.

The dose for children (8-13 years old) is 20 mg daily, and the dose for adolescents (14-18 years old) is 40 mg daily.

DRUG INTERACTIONS: Bile acid sequestrants such as cholestyramine (Questran) may reduce the absorption of pravastatin from the intestine and thereby reduce its effects. Therefore, pravastatin should be taken one hour before or four hours after bile acid sequestrants. The use of pravastatin with nicotinic acid, gemfibrozil (Lopid) or other drugs that cause liver or muscle problems may increase the risk of muscle problems.

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