pramoxine, Itch-X, PrameGel, and others (cont.)

Medical Author:
Medical and Pharmacy Editor:

DRUG INTERACTIONS: There are no drug interactions listed for pramoxine.

PREGNANCY AND BREASTFEEDING SAFETY: It is unknown whether pramoxine is harmful if used during pregnancy. It is unknown whether pramoxine is secreted into human milk.

STORAGE: Pramoxine should be stored at room temperature, 15-30 C (59-86 F).


  • Pramoxine is applied to the affected areas 3 to 4 times per day.
  • It is intended only for external use and should not be applied to open cuts or wounds or damaged skin.
  • If the condition does not improve after 7 days of use, a physician should be consulted.

DRUG CLASS AND MECHANISM: Pramoxine is a topical (used on the skin) anesthetic (numbing agent). Topical anesthetics are chemicals that interfere with the function of the nerves that sense pain. Pramoxine may be used in persons who are allergic to other local anesthetics such as lidocaine, procaine, or benzocaine.

Medically reviewed by Eni Williams, PharmD

Reference: FDA Prescribing Information

Medically Reviewed by a Doctor on 1/22/2016

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