What is the dosage for Mirapex?
Pramipexole can be taken with or without food.
Parkinson's disease initial treatment in patients with normal kidney function: The usual recommended starting dose (using immediate release tablets) is 0.375 mg/day given in three divided doses. Dosage may be increased gradually every 5 to 7 days.
Parkinson's disease maintenance treatment: The usual recommended dose range is 1.5 to 4.5 mg/day administered in equally divided doses every 8 hours.
Restless leg syndrome dosing: The recommended starting dose is 0.125 mg taken by mouth once daily 2-3 hours before bedtime. Dosage may be increased every 4-7 hours. Dosage should be increased every 14 days in RLS patients with severe or moderate kidney impairment.
Which drugs or supplements interact with Mirapex?
Pramipexole is a dopamine agonist. Effectiveness of pramipexole may be decreased when given with dopamine antagonists which are drugs with the opposite pharmacological effects. Examples of such drugs are:
- prochlorperazine (Compazine, Compro, Procomp),
- chlorpromazine (Promapar, Thorazine),
- fluphenazine (Permitil, Prolixin),
- haloperidol (Haldol),
- thioxanthenes (Navane), and
- metoclopramide (Reglan).
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