pramipexole (Mirapex, Mirapex ER)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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PRESCRIPTION: Yes

GENERIC AVAILABLE: Generics are available for the immediate release tablets. Generics of the extended release tablets are not available.

PREPARATIONS: Immediate release tablets: 0.125, 0.25, 0.5, 0.75, 1, and 1.5 mg; extended release 24 hour tablets: 0.375, 0.75, 1.5, 2.25, 3, 3.75, and 4.5 mg

STORAGE: Tablets should be stored at room temperature, between 15 C to 30 C (59 F to 86 F). Tablets should be protected from light and kept out of the reach of children.

DOSING: Pramipexole can be taken with or without food.

Parkinson's disease initial treatment in patients with normal kidney function: The usual recommended starting dose (using immediate release tablets) is 0.375 mg/day given in three divided doses. Dosage may be increased gradually every 5 to 7 days.

Parkinson's disease maintenance treatment: The usual recommended dose range is 1.5 to 4.5 mg/day administered in equally divided doses every 8 hours.

Restless leg syndrome dosing: The recommended starting dose is 0.125 mg taken by mouth once daily 2-3 hours before bedtime. Dosage may be increased every 4-7 hours. Dosage should be increased every 14 days in RLS patients with severe or moderate kidney impairment.

DRUG INTERACTIONS:Pramipexole is a dopamine agonist. Effectiveness of pramipexole may be decreased when given with dopamine antagonists which are drugs with the opposite pharmacological effects. Examples of such drugs are:

Medically Reviewed by a Doctor on 12/3/2014

Quick GuideRestless Legs Syndrome: Home Remedies for RLS and Better Sleep

Restless Legs Syndrome: Home Remedies for RLS and Better Sleep
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