pramipexole (Mirapex, Mirapex ER) (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
SIDE EFFECTS: The most common side effects reported are:
GENERIC AVAILABLE: Generics are available for the immediate release tablets. Generics of the extended release tablets are not available.
PREPARATIONS: Immediate release tablets: 0.125, 0.25, 0.5, 0.75, 1, and 1.5 mg; extended release 24 hour tablets: 0.375, 0.75, 1.5, 2.25, 3, 3.75, and 4.5 mg
STORAGE: Tablets should be stored at room temperature, between 15 C to 30 C (59 F to 86 F). Tablets should be protected from light and kept out of the reach of children.
DOSING: Pramipexole can be taken with or without food.
Parkinson's disease initial treatment in patients with normal kidney function: The usual recommended starting dose (using immediate release tablets) is 0.375 mg/day given in three divided doses. Dosage may be increased gradually every 5 to 7 days.
Parkinson's disease maintenance treatment: The usual recommended dose range is 1.5 to 4.5 mg/day administered in equally divided doses every 8 hours.
Restless leg syndrome dosing: The recommended starting dose is 0.125 mg taken by mouth once daily 2-3 hours before bedtime. Dosage may be increased every 4-7 hours. Dosage should be increased every 14 days in RLS patients with severe or moderate kidney impairment.
DRUG INTERACTIONS:Pramipexole is a dopamine agonist. Effectiveness of pramipexole may be decreased when given with dopamine antagonists which are drugs with the opposite pharmacological effects. Examples of such drugs are:
Medically Reviewed by a Doctor on 12/3/2014
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