pramipexole (Mirapex, Mirapex ER)

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GENERIC NAME: pramipexole

BRAND NAME: Mirapex, Mirapex ER

DRUG CLASS AND MECHANISM: Pramipexole (Mirapex) is used for the treatment of Parkinson's disease (PD) and restless leg syndrome (RLS). Pramipexole stimulates dopamine receptors in the brain. The exact mechanism of action of pramipexole in Parkinson's disease is unknown. However, treatment benefits are thought to be related to the stimulation of dopamine receptors in the area of the brain known as the striatum. Pramipexole may improve movement performance and activities of daily living in patients usually within 2-3 weeks of starting treatment. The exact mechanism of action of pramipexole for the treatment of RLS is unknown. Benefits of treatment are thought to be associated with stimulating dopamine receptors in the brain.

  • The US FDA approved pramipexole for the treatment of Parkinson's disease in July, 1997.
  • Extended release pramipexole (Mirapex ER) was approved by the FDA for the treatment of early Parkinson's disease in February, 2010.
  • In March 2010, the FDA extended the approval of the extended release formulation to the treatment of advanced, idiopathic Parkinson's disease.
  • Immediate release pramipexole was approved by the FDA for the treatment of moderate to severe primary RLS in November, 2006.

PRESCRIBED FOR: Pramipexole is used for the treatment of the signs and symptoms of idiopathic Parkinson's disease, and moderate-to-severe primary restless leg syndrome.

Medically Reviewed by a Doctor on 12/3/2014



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