Prader-Willi Syndrome

Can Prader-Willi syndrome be inherited?

Most cases of Prader-Willi syndrome are not inherited, particularly those caused by a deletion in the paternal chromosome 15 or by maternal uniparental disomy. These genetic changes occur as random events during the formation of reproductive cells (eggs and sperm) or in early embryonic development. Affected people typically have no history of the disorder in their family.

Rarely, a genetic change responsible for Prader-Willi syndrome can be inherited. For example, it is possible for a genetic defect that abnormally inactivates genes on the paternal chromosome 15 to be passed from one generation to the next.

Where can I find information about treatment for Prader-Willi syndrome?

These resources address treatment or management of Prader-Willi syndrome or some of its symptoms.

You might also find information on treatment of Prader-Willi syndrome in Educational resources and Patient support.

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