potassium citrate (Urocit-K) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

Mild to moderate hypocitraturia (Urinary citrate greater than 150 mg/day):

  • Take 10 mEq potassium citrate orally three times a day
  • Severe hypocitraturia (Urinary citrate less than 150 mg/day):
  • Take 30 mEq potassium citrate orally 2 times a day or 20 mEq 3 times a day; with meals or within 30 minutes after meals.
  • Maintenance:
  • To achieve urinary citrate 320 to 640 mg/day and urinary pH 6.0-7.0: Titrate dose to maximum of 100 mEq/day



PREPARATIONS: Potassium citrate is available in extended-release tablets. They are available in 5 mEq (540 mg), 10 mEq (1080 mg), and 15 mEq (1620 mg) strengths. The packets for oral solution were discontinued in the U.S.

STORAGE: Store potassium citrate tablets at room temperature in a tightly closed container.

DRUG INTERACTIONS: Potassium citrate should be used with caution with potassium-sparring diuretics, which can increase potassium levels in body and potentially lead to cardiac arrest.

Drugs that slow transit of food through the intestine may delay passage of potassium tablets through the digestive system and result in increased irritation, ulceration or narrowing of the small intestine. Examples of such drugs include atropine, loperamide (Imodium), liraglutide (Saxzenda, Victoza) and similar drugs.

Angiotensin converting enzyme (ACE) inhibitors (for example, enalapril [Vasotec]), angiotensin receptor blockers (ARB) drugs (for example, valsartan [Diovan]) and certain diuretics (for example, spironolactone [Aldactone] and triamterene [Dyrenium]) increase potassium levels, causing high potassium levels in the blood when combined with potassium supplements. Potassium blood levels should be measured regularly in these patients.

Medically Reviewed by a Doctor on 4/14/2015

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