potassium citrate (Urocit-K)

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GENERIC NAME: Potassium citrate

BRAND NAME: Urocit-K

DRUG CLASS AND MECHANISM: Potassium citrate is a urinary alkalinizing medication. It makes urine less acidic. Potassium citrate works by crystallizing stone-forming salts such as calcium oxalate, calcium phosphate, and uric acid within the urinary bladder by increasing the urinary pH and urine citrate levels. Urocit-k was approved in August 1985.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Potassium citrate is available in extended-release tablets. They are available in 5 mEq (540 mg), 10 mEq (1080 mg), and 15 mEq (1620 mg) strengths.

STORAGE: Store potassium citrate tablets at room temperature in a tightly closed container.

PRESCRIBED FOR: Potassium citrate is used for treating renal tubular acidosis with calcium stones, hypocitraturic calcium oxalate nephrolithiasis (kidney stones), and uric acid lithiasis with or without calcium stones.

DOSING: Dosing of potassium citrate is based on urinary citrate levels.

Mild to moderate hypocitraturia (Urinary citrate greater than 150 mg/day):

  • Take 10 mEq potassium citrate orally three times a day
  • Severe hypocitraturia (Urinary citrate less than 150 mg/day):
  • Take 30 mEq potassium citrate orally 2 times a day or 20 mEq 3 times a day; with meals or within 30 minutes after meals.
  • Maintenance:
  • To achieve urinary citrate 320 to 640 mg/day and urinary pH 6.0-7.0: Titrate dose to maximum of 100 mEq/day

DRUG INTERACTIONS: Potassium citrate should be used with caution with potassium-sparring diuretics, which can increase potassium levels in body and potentially lead to cardiac arrest.

Medically Reviewed by a Doctor on 5/27/2014



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