Post-Polio Syndrome (cont.)
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What research is being conducted on post-polio syndrome?
Scientists are working on a variety of investigations that may one day help individuals with post-polio syndrome. Some basic researchers are studying the behavior of motor neurons many years after a polio attack. Others are looking at the mechanisms of fatigue and are trying to discover the role played by the brain, spinal cord, peripheral nerves, the neuromuscular junction (the site where a nerve cell meets the muscle cell it helps activate), and the muscles.
Determining if there is an immunological link in post-polio syndrome is also an area of intense interest. Researchers who discovered inflammation around motor neurons or muscles are trying to find out if this is due to an immunological response.
Other investigators have discovered that fragments of the poliovirus, or mutated versions of it, are in the spinal fluid of some survivors. The significance of this finding is not known and more research is being done.
Where can I get more information?
For more information on neurological disorders or research programs funded by the National Institute of Neurological Disorders and Stroke, contact the Institute's Brain Resources and Information Network (BRAIN) at:
Information also is available from the following organizations:
Post-Polio Health International/
March of Dimes Foundation
Medically reviewed by Jon Glass, MD; American board of Psychiatry and Neurology
Medically Reviewed by a Doctor on 4/2/2014
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